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Effectiveness and tolerance of cephalexin in children

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Abstract

Oral cephalexin was used in 45 children, aged 3 weeks to 14 years in a medium dose of 27.4 mg/kg repeated every 6–8 hrs in 19 cases of pyelonephritis, 11 cases of pulmonary infection and 15 cases of various infections for an average of 14–21 days. Clinical and bacteriological results were excellent in UTI, favourable in the other groups, as far as to be objectivated. During the first hours of therapy blood and urine concentrations were measured. Maximum concentrations in serum after a single dose were reached by children older than 1 year after 1 hr with 25.15 mcg/ml, in infants only after 2 hrs with only 9.82 mcg/ml. Urine concentrations exceeded 1000 mcg/ml in 38 out of 42 patients. WBC and neutrophils were disminished, SGOT, SGPT and blood urea elevated, but remained within normal limits.

Zusammenfassung

45 Kinder im Alter von 3 Wochen bis 14 Jahren wurden mit Cephalexin oral in einer mittleren Dosis von 27,4 mg/kg in 6–8stündigen Abständen behandelt. Die Behandlungsdauer betrug 14–21 Tage. Indikation zur Behandlung waren in 19 Fällen Pyelonephritiden, in 11 Fällen Luftwegsinfekte, in 15 Fällen verschiedene Infektionen. Die klinischen und bakteriologischen Resultate waren bei den Pyelonephritiden sehr gut, bei den anderen Gruppen, soweit objektivierbar, gut. Im Anschluß an die erste Cephalexin-Gabe wurden Blut-und Urinkonzentrationen bestimmt. Maximale Serumkonzentrationen von 25,15 mcg/ml wurden jenseits des 1. Lebensjahres nach 1 Std, bei Säuglingen erst nach 2 Std und wesentlich niedriger (9,82 mcg/ml) erreicht. Die Urinkonzentrationen überstiegen in 38 von 42 Fällen 1000 mcg/ml. Zu Beginn, während und am Ende der Therapie wurden die Hämatopoese, die Leber- und Nierenfunktionen überprüft. Es kam zu signifikanten Verminderungen der Leukocyten und Neutrophilen, zum Anstieg der Eosinophilen, der SGOT, SGPT und des Harnstoffes i. S. Alle Werte bleiben jedoch innerhalb der Normgrenze.

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Authors and Affiliations

  1. Kinderkrankenhaus der Stadt Köln, Köln, Deutschland

    H. Helwig, H. Kunz & Ch. Hueppchen

  2. Kinderkrankenhaus St. Hedwig Freiburg, Freiburg, Deutschland

    H. Helwig, H. Kunz & Ch. Hueppchen

  3. Hygiene-Institut der Universität Köln, Köln, Deutschland

    H. Helwig, H. Kunz & Ch. Hueppchen

Authors
  1. H. Helwig
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  2. H. Kunz
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  3. Ch. Hueppchen
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Additional information

Presented in part before the 7th Internat. Congr. of Chemotherapy, Prague 1971.

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Helwig, H., Kunz, H. & Hueppchen, C. Effectiveness and tolerance of cephalexin in children. Z. Kinder-Heilk. 111, 307–314 (1972). https://doi.org/10.1007/BF00438598

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