Skip to main content
SpringerLink
Log in

Cell-specific mechanisms of estrogen receptor in the pituitary gland

  • Plenary lectures
  • Increasing complexity of in vitro models
  • Published:
Cell Biology and Toxicology Aims and scope Submit manuscript

Abstract

Analysis of the mechanism of action of estrogen receptor shows protein and mRNA polymorphism within distinct pituitary receptor-positive cells. The lactotropes exhibit unique properties in these mechanisms that distinguish them from gonadotropes. Therefore, this cell type constitutes an especially interesting model in the male as well as in the female for estrogen receptor studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

PRL:

prolactin

E2:

estradiol

ER:

estrogen receptor

GnRH:

gonadotropin releasing hormone

PMSG:

pugnant mare serum gonadotropin

References

  • Ben-Jonathan N, Liu JW. Pituitary lactotrophs. Endocrine, paracrine, juxtacrine and autocrine interactions. TEM. 1992;3:254–8.

    Google Scholar 

  • Chalbos D, Philips A, Rochefort H. Genomic cross-talk between the estrogen receptor and growth factor regulatory pathways in estrogen target tissues. Cancer Biol. 1994;5:361–8.

    Google Scholar 

  • Claret FX, Chapel S, Garces J et al. Two functional forms of the Xenopus laevis estrogen receptor translated from a single mRNA species. J Biol Chem. 1994;269:14047–55.

    Google Scholar 

  • Day RN, Koike S, Solkai M, Muramatsu M, Maurer RA. Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene. Mol Endocrinol. 1990;4:1964–71.

    Google Scholar 

  • Demay F, Tiffoche C, Thieulant ML. Sex- and cell-specific expression of an estrogen receptor isoform in the pituitary gland. Neuroendocrinology. 1996;63:522–9.

    Google Scholar 

  • Denef C, Baes M, Van der Schueren B, Cassiman JJ. Aggregate cell cultures as a tool for studying cell to cell communication in rat anterior pituitary. In: Tixier-Vidal A, Richard P, eds. Multihormonal regulations in neuroendocrine cells. Paris: Colloque INSERM; 1982; 110:451–8.

  • Dotzlaw H, Alkhalaf M, Murphy LC. Characterization of estrogen receptor variant mRNAs from human breast cancers. Mol Endocrinol. 1992;6:773–85.

    Google Scholar 

  • Ellerkmann E, Nagy GM, Frawley LS. Rapid augmentation of prolactin cell number and secretory capacity by an estrogen-induced factor released from the neurointermediate lobe. Endocrinology. 1991;129:838–42.

    Google Scholar 

  • Faye JC, Fargin A, Bayard F. Dissimilarities between the uterine estrogen receptor in cytosol of castrated and estradiol-treated rats. Endocrinology. 1986;118:2276–83.

    Google Scholar 

  • Fox SR, Harlan RE, Shivers BD, Pfaff DW. Chemical characterization of neuroendocrine targets for progesterone in the female rat brain and pituitary. Neuroendocrinology. 1990;51:276–83.

    Google Scholar 

  • Friend KE, Ang LW, Shupnik MA. Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary. Proc Natl Acad Sci USA. 1995;92:4367–71.

    Google Scholar 

  • Gasc JM, Baulieu EE. Regulation by estradiol of the progesterone receptor in the hypothalamus and pituitary: an immunohistochemical study in the chicken. Endocrinology. 1988;1122:1357–65.

    Google Scholar 

  • Geffroy-Roisne S, Duval J, Thieulant ML. Multiple forms of affinity labeled estrogen receptors in rat distinct pituitary cells. Endocrinology. 1992;1331:1503–10.

    Google Scholar 

  • Gharib SD, Wierman ME, Shupnik MA, Chin WW. Molecular biology of the pituitary gonadotropins. Endocrine Rev. 1990;11:177–99.

    Google Scholar 

  • Gourdji D, Laverriere JN. The rat proclatin gene: a target for tissue-specific and hormone-dependent transcription factors. Mol Cell Endocrinol. 1994;100:133–42.

    Google Scholar 

  • Horigome T, Golding TS, Quarmby VE, Lubahn DB, McCarty SRK, Korach KS. Purification and characterization of mouse uterine estrogen receptor under conditions of varying hormonal status. Endocrinology. 1987;121:2099–111.

    Google Scholar 

  • Horigome T, Ogata F, Golding TS, Korach KS. Estradiol-stimulated proteolytic cleavage of the estrogen receptor in mouse uterus. Endocrinology. 1988;123:2540–8.

    Google Scholar 

  • Jasper TW, Ruth MF, Ruh TS. Estrogen and antiestrogen binding to rat uterine and pituitary estrogen receptor: evidence for at least two physicochemical forms of the estrogen receptor. J Steroid Biochem. 1985;23:537–45.

    Google Scholar 

  • Keefer DA, Stumpf WE, Petrusz P. Quantitative autoradiographic assessment of [3H]-estradiol uptake in immunocytochemically characterized pituitary cells. Cell Tissue Res. 1976;166:25–35.

    Google Scholar 

  • Kikuta T, Yamamoto K, Namiki H, Hayashi S. Immunocytochemical localization of estrogen receptor in various anterior pituitary hormone cells of adult male and female rats. Acta Histochem Cytochem. 1993;26:609–14.

    Google Scholar 

  • Koike S, Sakai M, Muramatsu M. Molecular cloning and characterization of the rat estrogen receptor cDNA. Nucleic Acids Res. 1987;15:2499–513.

    Google Scholar 

  • Lubahn DB, McCarty KS Jr, McCarty KS Sr. Electrophoretic characterization of purified bovine, porcine, murine, rat and human uterine estrogen receptors. J Biol Chem. 1985;260:2515–26.

    Google Scholar 

  • Maurer RA. Estradiol regulates the transcription of the prolactin gene. J Biol Chem. 1982;257:2133–6.

    Google Scholar 

  • McGuire WL, Chamness GC, Fuqua SAW. Estrogen receptor variants in clinical breast cancer. Mol Endocrinol. 1992;1571–7.

  • Morel G, Dubois P, Benassayag C et al. Ultrastructural evidence of estradiol receptor by immunochemistry. Exp Cell Res. 1981;132:249–57.

    Google Scholar 

  • Murdoch FE, Byrne LM, Ariazi EA, Furlow JD, Meier DA, Gorski J. Estrogen receptor binding to DNA: affinity for nonpalindromic elements from the rat prolactin gene. Biochemistry. 1995;34:9144–50.

    Google Scholar 

  • Olsen MR, Van Oosbree TR, Mueller GC. Characterization of rabbit uterine estrogen receptor proteins by radioiodination and partial peptide mapping. Endocrinology. 1986;119:2177–85.

    Google Scholar 

  • Parker CR Jr, Costoff A, Muldoon TG, Mahesh VB. Actions of pregnant mare's serum gonadotropin in the immature female rat: correlative changes in blood steroids, gonadotropins, and cytoplasmic estradiol receptors of the anterior pituitary and hypothalamus. Endocrinology. 1876;98:129–38.

    Google Scholar 

  • Pfeffer U, Fecarotta E, Arena G, Forlani A, Vidali G. Alternative splicing of the estrogen receptor primary transcript normally occurs in estrogen receptor positive tissues and cell lines. J Steroid Biochem Mol Biol. 1996;56:99–105.

    Google Scholar 

  • Power RF, Conneely OM, O'Malley BW. New insights into activation of the steroid hormone receptor superfamily. TIPS. 1992;13:318–23.

    Google Scholar 

  • Puca GA, Abbondanza C, Nigro V, Armetta I, Medici N, Molinari AM. Estradiol receptor has proteolytic activity that is responsible for its own transformation. Proc Natl Acad Sci USA. 1986;83:5367–73.

    Google Scholar 

  • Raymond V, Baulieu M, Labrie F, Boissier J. Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release. Science. 1978;200:1173–5.

    Google Scholar 

  • Shull JD, Gorski J. Estrogen regulates the transcription of the rat prolactin gene in vivo through at least two independent mechanisms. Endocrinology. 1985;116:2456–62.

    Google Scholar 

  • Shupnik MA, Gordon MS, Chin WW. Tissue specific regulation of rat estrogen receptor mRNAs. Mol Endocrinol. 1989;3:660–5.

    Google Scholar 

  • Singh P, Muldoon TG. Specific, estrogen-sensitive alterations in anterior pituitary cytoplasmic and nuclear estrogen receptors activated by LHRH. Neuroendocrinology. 1983;37:98–105.

    Google Scholar 

  • Sprangers SA, West NB, Brenner RM, Bethea CL. Regulation and localization of estrogen and progestin receptors in the pituitary of steroid-treated monkeys. Endocrinology. 1990;126:1133–42.

    Google Scholar 

  • Thieulant ML, Duval J. Differential distribution of androgen and estrogen receptors in rat pituitary cell populations separated by centrifugal elutriation. Endocrinology. 1985;116:1299–303.

    Google Scholar 

  • Thieuland ML, Sion B, De Monti M, Duval J. Binding of estradiol and 5-α-androstan-3ß, 17ß-diol by the male rat enriched gonadotrope cells. J Steroid Biochem. 1984;20:373–6.

    Google Scholar 

  • Tong Y, Zhao H, Labrie F, Pelletier G. Effects of estrogens on the ultrastructural characteristics of female rat prolactin cells as evaluated by in situ hybridization in combination with immunogold staining technique. Neuroendocrinology. 1990;52:309–15.

    Google Scholar 

  • Toulas C, Beauregard G, Delassus F et al. Target size analysis of estrogen receptor in cultured intact cells: change in receptor structure between subconfluency and superconfluency in culture. Mol Cell Endocrinol. 1990;72:89–94.

    Google Scholar 

  • Toulas C, Barraille P, Delassus F, Bayard F, Prats H, Faye JC. Differential initiation of translation of a single estrogen receptor mRNA could explain some estradiol resistance cases. Horm Res. 1992;38:73–7.

    Google Scholar 

  • Turgeon JL, Waring DW. Functional cross-talk between receptors for peptide and steroid hormones. TEM. 1992;3:360–5.

    Google Scholar 

  • Weisenberg LS, De Nicola AF, Arakelian MC, Libertun C. Effect of median eminence lesions on (3H)estradiol binding in the anterior pituitary and hypothalamus. Endocrinology. 1979;105:1152–7.

    Google Scholar 

  • Weiss J, Jameson JL, Burrin JM, Crowley WF Jr. Divergent responses of gonadotropin subunit messenger RNAs to continuous versus pulsatile gonadoropin-releasing hormone in vitro. Mol Endocrinol. 1990;4:557–64.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire d'Endocrinologie Moléculaire de la Reproduction, Centre National de la Recherche Scientifique, Rennes Cedex, France

    F. Demay, S. Geffroy, C. Tiffoche, M. de Monti & M. L. Thieulant

Authors
  1. F. Demay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Geffroy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Tiffoche
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. de Monti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. L. Thieulant
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Demay, F., Geffroy, S., Tiffoche, C. et al. Cell-specific mechanisms of estrogen receptor in the pituitary gland. Cell Biol Toxicol 12, 317–324 (1996). https://doi.org/10.1007/BF00438164

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00438164

Keywords

Search

Navigation