Abstract
The effects of protriptyline and clomipramine, at concentrations of 10−7 M to 10−4 M, were studied in vitro on the uptake of 5-hydroxytryptamine and dopamine uptake in human platelet-rich plasma. It was found that the tertiary amine, clomipramine, was a more potent inhibitor of 5-hydroxytryptamine uptake than the secondary amine, protriptyline. The activity of both compounds was competitive but it was thought unlikely that they acted through tryptamine receptor sites as methysergide 2.5×10−8 M had very little effect on 5-hydroxytryptamine uptake. Neither tricyclic antidepressant had any marked effect on dopamine uptake.
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A. T. was supported by a grant from the Mental Health Research Fund.
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Trenchard, A., Turner, P., Pare, C.M.B. et al. The effects of protriptyline and clomipramine in vitro on the uptake of 5-hydroxytryptamine and dopamine in human platelet-rich plasma. Psychopharmacologia 43, 89–93 (1975). https://doi.org/10.1007/BF00437621
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DOI: https://doi.org/10.1007/BF00437621