Abstract
The take up time of a standardized alimentary material is a simple component of hamster hoarding behaviour. This value was modified by administrations of the following compounds: diazepam, chlorpromazine, meprobamate, apomorphine, d-amphetamine, piribedil, fenfluramine, sulpiride, imipramine, phenobarbital, clonidine and morphine. The change consisted of a varying increase in the take up time, dependent upon the substance and dosage. High doses of chlorpromazine, apomorphine and fenfluramine inhibited the take up. A behavioural study connected with alimentary take up was included in the experiment. Some behavioural modifications (increase or decrease in motor activity, myorelaxation, stereotyped exploration, reciprocating movements) demonstrated differences between the studied compounds related to their pharmacological properties. The immediate consumption of food, without take up and hoarding behaviour, observed with meprobamate treatment, was an interesting and unexpected change in hamster behaviour. The measurement of the take up time and analysis of behavioural modifications may be useful in comparing and preliminary screening of new psychopharmacological compounds.
Résumé
Le temps de ramassage d'un matériel alimentaire standard est une composante simple du comportement de stockage chez le Hamster. Cette valeur est modifiée par différentes administrations des composés suivants: Diazepam, Chlorpromazine, Méprobamate, Apomorphine, d-Amphétamine, Piribédil, Fenfluramine, Sulpiride, Imipramine, Phénobarbital, Clonidine et Morphine. La modification consiste en une augmentation plus ou moins grande du temps de ramassage selon la substance employée et selon la dose administrée. Des doses élevées de Chlorpromazine, Apomorphine et Fenfluramine inhibent le ramassage. De plus, une étude comportementable liée au ramassage alimentaire est incluse dans la méthode. Certaines modifications (augmentation ou diminution d'activité motrice, myorelaxation, exploration stéréotypée, déplacements de va-et-vient) permettent une distinction entre les substances étudiées, selon leur classification pharmacologique. La consommation immédiate de nourriture, sans ramassage et comportement de stockage, constatée lors du traitement par le Meprobamate, est une modification imprévue et intéressante du comportement alimentaire du Hamster. La mesure du temps de ramassage et l'analyse des modifications comportementales semblent utiles dans la comparaison et l'orientation préliminaire des nouvelles substances psychopharmacologiques.
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Poignant, J.C., Rismondo, N. Influence de l'administration de composés neurotropes sur le temps de ramassage d'un matériel alimentaire chez le hamster, et étude du comportement associé. Psychopharmacologia 43, 47–52 (1975). https://doi.org/10.1007/BF00437614
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DOI: https://doi.org/10.1007/BF00437614