Mycopathologia

, Volume 110, Issue 3, pp 177–181 | Cite as

Chlamydosporol, a new metabolite from Fusarium chlamydosporum

  • Marc E. Savard
  • J. David Miller
  • Baharuddin Salleh
  • Richard N. Strange
Article

Abstract

Extracts of rice on which an isolate of Fusarium chlamydosporum had been cultured were toxic to brine shrimps. The toxic fraction was purified by flash chromatography to give two compounds which were identified by UV, IR, NMR and mass spectroscopy at the 6α and 6β isomers of 5-hydroxy-4-methoxy-6, 8a-dimethyl-6,7-dihydro-2H,8aH-pyrano[2,3-b]pyran-2-one. These lactones for which the name chlamydosporol is proposed have not been reported previously. When tested in brine shrimp and HeLa cell assays, the LC50 concentration for a mixture of the isomers was approximately 400 μg/ml in both systems.

Key words

Chlamydosporol Fusarium chlamydosporum mycotoxin 

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Marc E. Savard
    • 1
  • J. David Miller
    • 1
  • Baharuddin Salleh
    • 2
  • Richard N. Strange
    • 2
  1. 1.Plant Research CentreAgriculture CanadaOttawa
  2. 2.Department of Biology, Darwin BuildingUniversity College LondonLondonUK

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