Abstract
The ability of a killer yeast (Pichia anomala, UCSC 25F) to produce toxin in vivo was demonstrated, for the first time, in tissues of normal and immunosuppressed experimentally infected mice by means of a fluorescent antibody technique and a killer toxin specific monoclonal antibody. The possible significance of the findings is discussed.
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References
Bevan EA, Makower M. The physiological basis of the killer character in yeast. Proc XI Int Congr Genet 1963; 1: 203.
Collins JP, Grappel SF, Blank F. Role of keratinases in dermatophytosis. II. Fluorescent antibody studies with keratinase II of Trichophyton mentagrophytes. Dermatologica 1973; 146: 95–100.
Csilog A, Bradstein L. The role of a Blastomyces species in the genesis of interstitial pneumonia of the premature infant. Acta microbiol Acad Sci Hung 1954; 9: 299–306.
Grocott RG. A stain for fungi in tissue sections and smears using Gomori's methenamine-silver nitrate technic. Amer J Clin Path 1955; 25: 975–979.
Iwata K, Uchida K, Hamajiima K, Kawamura A. Role of canditoxin in experimental Candida infection. Symposium on toxins. J Med sci Biol 1974; 27: 130–133.
Kandel JS. Killer systems in pathogenic yeast, pp. 259–262. In E.S. Kuttin and G.L. Baum (ed.), Human and animal mycology. Int. Congr. Series N1, 480. Excerpta Medica, Amsterdam, 1980.
Kandel JS, Koltin Y. Killer phenomenon and double stranded RNA in Candida and Torulopsis species. Abstr Ann Meet Am Soc Microbiol 1981; 191.
Kwon-Chung KJ, Lehman D, Good C, Magee PT. Genetic evidence for role of extracellular proteinase in virulence of Candida albicans. Infect Immun, 1985; 49: 571–575.
Marsh P, Martin M. Oral Microbiology, pp. 58–59. Van Nostrand Reinhold Co. Ltd, 2nd ed., UK. 1984.
McGinnis MR, Walker DH, Folds JD. Hansenula polymorpha infections in a child with chronic granulomatous disease. Acta Pathol Lab Med, 1980; 104: 290–292.
Middlebeek EJ, Hermans JMH, Stumm C, Muytjens HL. High incidence of sensitivity to yeast killer toxins among Candida and Torulopsis isolated of human origin. Antimicrob Agents Chemother. 1980; 17: 350–354.
Morace G, Archibusacci C, Sestito M, Polonelli L. Strain differentiation of killer yeasts by the killer system. Mycopathologia 1984; 84: 81–85.
Murphy N, Damianovic V, Hart CA, Buchanan CR, Whitaker R, Cooke RWI. Infection and colonisation of neonates by Hansenula anomala. The Lancet, February 8. 1986.
Philliskirk G, Young TW. The occurrence of killer character in yeasts of various genera. Antonie van Leeuwenhoek, 1975; 41: 147–151.
Polonelli L, Castagnola M, Rossetti DV, Morace G. Use of killer toxins for computer-aided differentiation of Candida albicans strains. Mycopathologia 1985; 91: 175–179.
Polonelli L, Morace G. Reevaluation of the yeast killer phenomenon. J clin Microbiol 1986; 24: 866–869.
Polonelli L, Morace G. Production and characterization of yeast killer toxin monoclonal antibodies. J clin Microbiol., 1987; 25: 460–462.
Polonelli L, Manzara S, Conti S, Dettori G, Morace G. Serological study of yeast killer toxins by monoclonal antibodies. Mycopathologia 1989; 108: 211–215.
Rogers D, Bevan EA. Group classification of killer yeasts based on cross reactions between strains of different species and origin. J gen Microbiol 1978; 105: 199–202.
Stamer WT, Ganter PF, Aberdeen V, Lachance M-A, Phaff HJ. The ecological role of killer yeasts in natural communities of yeasts. Can J Microbiol 1987; 33: 783–796.
Wang CJK, Schwarz J. The etiology of interstitial pneumonia: identification as Hansenula anomala of a yeast isolated from lungs of infants. Mycopathol Mycol Appl, 1958; 9: 299–306.
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Polonelli, L., Conti, S., Gerloni, M. et al. Production of yeast killer toxin in experimentally infected animals. Mycopathologia 110, 169–175 (1990). https://doi.org/10.1007/BF00437542
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DOI: https://doi.org/10.1007/BF00437542