Abstract
Obomycosis is a dermal mycosis produced by Loboa loboi. It gives rise to dermal granulomas in which giant cells phagocytose an overwhelming number of fungi. Intracytoplasmatic asteroid bodies (AB) have been observed in some giant cells. Their nature is unknown and they have been confused with the sporotrichotic AB. We studied 84 skin biopsies from 53 patients with lobomycosis, 7 by electron microscopy (EM). Immunohistochemistry with a polyclonal anti-Sporothrix schenckii antibody was performed in five biopsies. We found AB in the giant cells in 22 of the 84 biopsies on HE staining. They appeared as single eosinophilic intracytoplasmic structures surrounded by a clear empty space. This clear space did not appear when the biopsy was fixed with OsO4, thus indicating that it is lipid in nature, and that the vacuole is an artefact produced by lipid extraction. Under the EM, the AB consist of bundles of dense, filamentous material, dense bodies and myelin structures resembling the image of AB in sarcoidosis. Some giant cells containing AB either phagocytosed only few fungi or did not contain any of them. The AB and the fungi did not react with the anti-sporotrichotic antibody, which stained the extracellular AB of sporotrichosis. These two asteroid structures are, therefore, different and unrelated phenomena.
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References
Rodríguez G. Lobomycosis. Int J Dermatol 1993; 32: 324–32.
Rodríguez G, Tellez N. Lobomycosis in Colombian American Indian patients. Mycopathologia 1992; 120: 5–9.
Silva D, Neves C. Dois casos novos da micose de lobo: actualizaçao estatística. An bras Dermatol 1995; 70: 127–9.
Michalany J. Corpos asteroides nas lesoes granulomatosas, com especial referencia a blastomicose ou doença de “Jorge Lobo”. Rev Assoc med Brasil 1955; 2: 61–8.
Michalany J. Corpos asteroides na blastomicose de Jorge Lobo. Rev Inst Med trop Sao Paulo 1963; 5: 33.
Azulay RD, Carneiro JA, Andrade LC. Blastomicose de Jorge Lobo. An Brasil Dermat 1970; 45: 47–66.
Azar H, Lunardelli C. Collagen nature of asteroid bodies of giant cells in sarcoidosis. Am J Pathol 1969; 57: 81–92.
Cain H, Kraus B. Asteroid bodies: derivatives of the cytosphere. An electron microscopic contribution to the pathology of the cytocentre. Virchows Archiv B Cell Pathol 1977; 26: 119–32.
Kirkpatrick JC, Curry A, Bisset DL. Light- and electronmicroscopic studies on multinucleated giant cells in sarcoid granuloma: new aspects of asteroid and Schaumann bodies. Ultrastruct Pathol 1988; 12: 581–97.
Papadimitriou JC, Drachenberg CB. Ultrastructural analysis of asteroid bodies: evidence for membrane lipid bilayer nature of components. Ultrastruct Pathol 1992; 16: 413–21.
Ackerman AB. Histologic diagnosis of inflammatory skin diseases. A method by pattern analysis, 1st ed. Philadelphia: Lea & Febiger, 1978: 432.
Schwarz J. The diagnosis of deep mycosis by morphologic methods. Hum Pathol 1982; 13: 519–33.
Rodríguez G. The asteroid body of sporotrichosis. Submitted for publication.
De Andrade LC, Azulay RD, Carneiro JA. Micose de Jorge Lobo. Hospital 1968; 73: 177–88.
Wiersema JP, Niemel PLA. Lobo's disease in Surinam patients. Trop Geogr Med 1965; 17: 89–111.
Cunningham JA. Characteristics of stellate inclusions in giant cells and associated tissue reactions. Am J Pathol 1951; 27: 761–81.
Kay S. Sarcoidosis of the spleen. Am J Pathol 1950; 26: 437–43.
Teilum G. The nature of double contoured and stratified intracellular bodies in sarcoidosis. Am J Pathol 1949; 25: 85–91
Rodríguez G. El cuerpo asteroide de la esporotricosis. Especificidad y diferenciación do otras formas asteroides. Biomedica 1985; 5: 11–23.
Hiruma M, Kawada A, Ishibashi A. Ultrastructure of asteroid bodies in sporotrichosis. Mycoses 1991; 34: 103–7.
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Rodríguez, G., Barrera, G.P. The asteroid body of lobomycosis. Mycopathologia 136, 71–74 (1996). https://doi.org/10.1007/BF00437498
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DOI: https://doi.org/10.1007/BF00437498