Abstract
Rats were infected with Coccidioides immitis and injected with cyclophosphamide three days pre or post infection.
Administration of the drug before the infection caused enhancement of DTH response and decrease of the colony forming units (CFU). Conversely, injection of the drug three days post infection produced contrary effects, indicating that a normal T-cell function is essential as a defense mechanism in C. immitis infection.
Similar content being viewed by others
References
Aguilar-Torres FG, Jackson LJ, Ferestenfeld JE, Pappagianis D, Rytel MW: Counterimmunoelectrophoresis in the detection of antibodies against Coccidioides immitis. Annals of Internal Medicine. 85:740–744, 1976.
Beamon L, Pappagianis D, Benjamini E: Significance of T-cells in resistance to experimental murine coccidioidomycosis. Infect Immun 17:580–585, 1977.
Beamon L, Pappagianis D, Benjamini E: Mechanisms of resistance to infection with Coccidioides immitis in mice. Infect Immun 23:681–685, 1979.
Boyden S: The absorption of proteins in erythrocytes treated with tannic acid and subsequent hemagglutination by antiproteins sera. J Exp Med 93:107–120, 1951.
Catanzaro A, Spitler L, Moser KM: Cellular immune responses in coccidiodomycosis. Cell Immunol 15:360–371, 1975.
Cox RA, Brummer E, Lecara G: In vitro Lymphocyte responses of coccidiodin skin test-positive and negative persons to coccidioidin, spherulin and Coccidioides cell wall antigen. Infect Immun 15:751–755, 1977.
Cox RA, Vivas JR: Spectrum of in vivo and in vitro cell-mediated immune responses in coccidioidomycosis. Cell Immunol 31:130–141, 1977.
Cox RA, Arnold DR: Immunoglobulin E in coccidioidomycosis. J Immunol 123:194–200, 1979.
Deepe JR, Kravitz GR, Bullock WE: Pharmacological modulation of suppressor cell activity in mice with disseminated histoplasmosis. Infect Immun 41:114–120, 1983.
Finerty JF, Krehl EP: Cyclophosphamide pretreatment and protection against malaria. Infect Immun 14:1103–1105, 1976.
Graybill JR, Mitchell L: Cyclophosphamide effects on murine cryptococcosis. Infect Immun 21:674–677, 1978.
Harvey PR, Stevens DA: In vitro assays of cellular immunity in progressive coccidioidomycosis. Am Rev Respir Dis 123:665–669, 1981.
Huppert M, Sun SH, Gross AJ: Evaluation of an experimental animal model for testing antifungal substances. Antimicrob Agents Chemother 1:367–372, 1972.
Mitsuoka A, Baba M, Morikawa S: Enhancement of delayed hypersensitivity by depletion suppressor T-cells with cyclophosphamide in mice. Nature (London) 262:77–78, 1976.
Omieczynsky DT, Swatek FE, Becker SW: A rapid method or the isolation of Coccidioides immitis from sputum. Healthy Lab Sci 2:35–39, 1965.
Pappagianis D, Saito M, Van Hoosear KH: Antibody in cerebrospinal fluid in non-meningitic coccidioidomycosis. Sabouraudia 10:173–179, 1972.
Pappagianis D: Epidemiology of coccidioidomycosis. In: Stevens DA, (ed) Coccidioidomycosis: a text. New York, Plenum Press: 63–85, 1980.
Pappagianis D: Serology and serodiagnosis of coccidioidomycosis. In: Stevens DA, ed Coccidioidomycosis: a text New York, Plenum Press: 97–112, 1980.
Parker D, Dwyer JM, Turk JL: The effect of cyclophosphamide and role of suppressor cell in the desensitization of delayed hypersensitivity. Immunology 43:191–196, 1981.
Ramshaw IA, Brescher PA, Parish CR: Regulation of the immune response. II. Repressor T-cells in cyclophosphamide-induced tolerant mice. Eur J immunol 7:180–185, 1977.
Riera CM, Galmarini M, Serra H: Specific suppression of humoral and delayed hypersensitivity responses by cyclophosphamide in an experimental model of autoimmunity. Am J Reprod Immunol 4:71–75, 1983.
Riera CM, Masih DT, Rubinstein H, Nobile R, Vega VR: Effect of cyclophosphamide on rats experimentally infected with Cryptococcus neoformans. Mycopathology 88:127–130, 1984.
Serra HM, Galmarini M, Vottero-Cima E, Riera CM: The effect of cyclophosphamide on autoimmune response to rats immunized with modified accessory glands. Int J Imm Pharmac 5:67–70, 1983.
Singer SH, Noguchi P, Kirschstein RL: Respiratory disease in Cyclophosphamide-treated mice. II Decreased virulence of PR8 influenza virus. Infect Immun 5:957–960, 1972.
Smith CE, Whiting EG, Baker EE, Rosenberger RR, Beard RR, Saito MT: The use of coccidioidin. Am Rev Tuberc 57:330–360, 1948.
Stavitsky AB: Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. J Immunol 72:360–367, 1954.
Thomas JW, Danho W, Bullesbach E, Föhles J, Rosenthal AS: Immune response gene control of determinant selection. III. Polypeptide fragments of insulin are differentially recognized by T but not by B cells in insulin immune guinea pigs. J Immunol 126:1095–1100, 1981.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rubinstein, H.R., Masih, D.T., Marticorena, B. et al. Experimental coccidioidomycosis: Effects of cyclophosphamide in immunologic responses. Mycopathologia 94, 91–95 (1986). https://doi.org/10.1007/BF00437373
Issue Date:
DOI: https://doi.org/10.1007/BF00437373