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Non-specific immunosuppression in experimental cryptococcosis in rats

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Abstract

The delayed type hypersensitivity response to human serum albumin (HSA) of rats infected intraperitoneally with 107 viable C. neoformans cells, and 7 days after, immunized with human serum albumin was significantly diminished (p<0.05) when compared with the response observed in rats immunized with human serum albumin and non infected. The spleen mononuclear cells from suppressed rats transferred to normal syngeneic recipients of the same sex suppress the afferent phase of the response (p<0.02) suggesting that cells present in the spleen might be one of the responsible mechanisms for the suppression to nonrelated antigens in infected animals.

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Authors and Affiliations

  1. Cátedras de Inmunología y Serología y Parasitología y Micología, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

    Diana T. Masih, Héctor R. Rubinstein, Claudia E. Sotomayor, María E. Ferro & Clelia M. Riera

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  1. Diana T. Masih
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  2. Héctor R. Rubinstein
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  3. Claudia E. Sotomayor
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  4. María E. Ferro
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  5. Clelia M. Riera
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Masih, D.T., Rubinstein, H.R., Sotomayor, C.E. et al. Non-specific immunosuppression in experimental cryptococcosis in rats. Mycopathologia 94, 79–84 (1986). https://doi.org/10.1007/BF00437371

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