, Volume 97, Issue 3, pp 173–178 | Cite as

Esterogenic effect of zearalenone on the uterine acetyl cholinesterase in female rats

  • A. Y. Nassar
  • S. E. Megalla
  • A. H. Hafez


A single dose of zearalenone (10 μg/g LBW) was injected intraperitoneally to Wistar Albino rats at the age of 50–100 days. The uterine acetyl cholinesterase enzyme was significantly increased in the treated animals compared to that in the controls. Therefore, zearalenone would be considered as an esterogenic effector for increasing the uterine acetyl cholinesterase which enhances uterine relaxation and subsequently improves its function for pregnancy in prematured-animals.

Unlike estradiol, it was interesting to find that the estrogenicity of zearalenone was increased by the moderating progesterone hormone. Moreover, it was revealed in this study that the injected dose of zearalenone had no deleterious effects on the pregnant rats at 10–12 days period of gestation. The harmful effects of zearalenone on pregnant animals cited in the literature (11, 13, 19) were reviewed.


Enzyme Progesterone Single Dose Estradiol Acetyl 
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Copyright information

© Martinus Nijhoff/Dr W. Junk Publishers 1987

Authors and Affiliations

  • A. Y. Nassar
    • 1
  • S. E. Megalla
    • 1
  • A. H. Hafez
    • 1
  1. 1.Departments of Biochemistry, Botany and Animal HygieneUniversity of AssiutAssiutEgypt

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