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Diagnosis of disseminated candidiasis in hospitalized patients using the Cand-Tec latex agglutination assay

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Abstract

A total of 1,303 sera from 202 patients at risk for disseminated candidiasis were analyzed for the presence of Candida antigen using a commercially available latex agglutination test (Cand-Tec). Twentythree patients had disseminated candidiasis documented by positive blood cultures, deep biopsy culture and histopathology or autopsy. Six patients had transient candidemia, 15 patients had candiduria, 62 patients were not colonized yet treated empirically with amphotericin B, and 46 patients were not colonized and not treated with amphotericin B. The sensitivity and specificity of the Candida antigen test for the diagnosis of disseminated candidiasis was 87% and 36% (threshold titer of ⩾1∶2), 70% and 60% (⩾1∶4), and 30% and 85% (⩾1∶8), respectively. In contrast to previous studies we were unable to demonstrate a prognostic role for the Candida antigen test in patients with documented disseminated candidiasis. The lack of sensitivity and specificity of the Cand-Tec Candida antigen test precludes its use in the diagnosis of disseminated candidiasis.

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Authors and Affiliations

  1. Department of Pathology, University of Iowa College of Medicine, 52242, Iowa City, IA

    Martha L. Sanchez, Ignacio Cabezudo, Martha Bale & Barry Buschelman

  2. Department of Pathology, Oregon Health Sciences University, 97201-3098, Portland, OR, USA

    Michael A. Pfaller

Authors
  1. Martha L. Sanchez
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  2. Michael A. Pfaller
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  3. Ignacio Cabezudo
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  4. Martha Bale
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  5. Barry Buschelman
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Sanchez, M.L., Pfaller, M.A., Cabezudo, I. et al. Diagnosis of disseminated candidiasis in hospitalized patients using the Cand-Tec latex agglutination assay. Mycopathologia 118, 153–162 (1992). https://doi.org/10.1007/BF00437148

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  • DOI: https://doi.org/10.1007/BF00437148

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