Abstract
Experimental central nervous system (CNS) phaeohyphomycosis was established in cortisone-treated mice following intranasal exposure to conidia of Xylohypha bantiana (Cladosporium bantianum, C. trichoides). X. bantiana was recovered from the lungs of 78% of intranasally inoculated normal mice sacrificed within the first 3 days of infection and from 15% at day 28. The fungus was not recovered from the brains of normal mice. In contrast, X. bantiana was recovered from only 33% of the lungs of cortisone-treated mice within the first 3 days of infection. However, the fungus was recovered from the brains of 11% of cortisone-treated mice sacrificed or dying over a 28 day period. Histologically and temporally the CNS disease in cortisone-treated, intranasally inoculated mice was consistent with hematogenous dissemination from a primary pulmonary focus.
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References
Apabuukuu AA. Reactive processes in the early stages of brain mycosis. In Russian. Arkiv Patologii 1968; 30:17–23.
Aravyski RA, Aronson VB. Comparative histopathology of chromomycosis and cladosporiosis in the experiment. Mycopathol et Mycol Applicata 1968; 36:322–340.
Claesson MH, Ropke C. Colony formation by subpopulations of T lymphocytes. IV. Inhibitory effect of hydrocortisone on human and murine T cell subsets. Clin Exper Immunol 1983; 54:554–560.
De Mello MT, Cedillos RA, De Jimeniz GG, Trejos A. Infeccion in vitro e in vivo de histiocitos alveolares por Cladosporium trichoides, agente de abscesos cerebrales en el hombre. Anais de Microbiologia 1964; 12:75–84.
Dixon DM, Shadomy HJ, Shadomy S. Isolation of Cladosporium trichoides from nature. Mycopathologia 1977; 62:125–127.
Dixon DM, Shadomy HJ, Shadomy S. Dematiaceous fungal pathogens isolated from nature. Mycopathologia 1980; 70:153–161.
Emmons CW, Binford CH, Utz JP, Kwon-Chung KJ. Medical mycology. 3rd ed. Philadelphia: Lea & Febiget 1977: 472.
Fiske RA, Choyce PD, Whitford HW, Martin EC. Phaeohyphomycotic encephalitis in two dogs. J Am Animal Hosp Assoc 1986; 22:237–330.
Iwatsu T. A new species of Cladosporium from Japan. Mycotaxon 1984; 20:521–533.
Jang SS, Biberstein EL, Rinaldi MG, Henness AM, Boorman GA, Taylor RF. Feline brain abscess due to Cladosporium trichoides. Sabouraudia 1977; 15:115–123.
Klite PB, Kelley HB, Dierks FN. A new soil sampling technique for pathogenic fungi. Am J Clin Epidemiol 1965; 31:124–130.
Mandal A, Mohapatra LN. Experimental cladosporiosis. I. Artificial respiratory infection. Indian J Microbiol 1973; 12:205–208.
McGinnis MR. Chromoblastomycosis and phaeohyphomycosis: New concepts, diagnosis, and mycology. Amer Acad Dermatol St. Louis 1983; 8:1–16.
McGinnis MR, Borelli D, Padhye AA, Ajello L. Reclassification of Cladosporium bantianum in the genus Xylohypha. J Clin Microbiol 1986; 23:1148–1151.
Merkow L, Pardo M, Epstein SM, Verney E, Sidransky H. Lysosomal stability during phagocytosis of Aspergillus flavus spores by alveolar macrophages of cortisone-treated mice. Science 1978; 160:79–81.
Newsholme SJ, Tyrer MJ. Cerebral mycosis in a dog caused by Cladosporium trichoides Emmons 1952. Onderstepoort J Vet Research 1980; 47:47–49.
Nishimura K, Miyaji M. Cladosporium trichoides and its parasitic forms in congenitally athymic nude mice and their heterozygous littermates. Mycopathologia 1985; 90:21–28.
Piggott W, Emmons CW. Device for inhalation exposure of animals to spores. Proc Soc Exp Biol Med 103:805–806.
Reed C, Fox JG, Campbell LH. Leukaemia in a cat with concurrent Cladosporium infection. J Small Animal Practice 1974; 15:55–62.
Richard JL, Thurston JR. Rapid hematogenous dissemination of Aspergillus fumigatus and A. flavus spores in turkey poults following aerosol exposure. 1983; 29:1025–1033.
Rogers P, Matossian-Rogers A. Differential sensitivity of lymphocyte subsets to corticosteroid treatment. Immunology 1982; 46:841–848.
Rowatt JD, Hill JO, Lundgren DL. Respiratory infection of cyclosphosphamide-treated mice with Pseudomonas aeruginosa. Exp Lung Res 1983; 5:305–316.
Saito Y, Tsuchiya T, Nomura Y, Takenaka M, Tabuchi K. Three cases of mycosis in Amazona aestiva. Bulletin Azuba Vet College 1967; 1:47–53.
Schaffner A. Therapeutic concentrations of glucocorticoids suppress the antimicrobial activity of human macrophages without impairing their responsiveness to gamma-interferon. J Clin Invest 1985; 76:1755–1764.
Schaffner A, Davis CE, Schaffner T, Markert M, Douglas H, Braude AI. In vitro susceptibility of fungi to killing by neutrophil granulocytes discriminates between primary pathogenecity and opportunism. J Clin Invest 1986; 78:511–524.
Schaffner A, Douglas H, Braude A. Selective protection against conidia by macrophages and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. J Clin Invest 1982; 69:619–631.
Shinwari MW, Thomas AD, Orr JD. Feline cerebral phaeohyphomycosis associated with Cladosporium bantianum. Australian Vet J 1985; 62:383–384.
Van Dijk H, Bloksma N, Rademaker PM, Schouten WJ, Willers JM. Differential potencies of corticosterone and hydrocortisone in immune and immune-related processes in the mouse. Internat J Immunopharmacol 1979; 1:285–292.
Walsh TJ, Dixon DM, Polak A, Salkin I. Comparative histopathology of Dactylaria constricta, Fonsecaea pedrosoi, Wangiella dermatitidis, and Xylohypha bantiana in experimental phaeohyphomycosis of the central nervous system. Mykosen 1987; 30:215–225.
Walsh TJ, McEntee C, Dixon DM. Tissue homogenization for quantitative cultures of Candida albicans using sterile reinforced polyethylene bags. J Clin Microbiol 1987; 25: 931–932.
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Dixon, D.M., Merz, W.G., Elliott, H.L. et al. Experimental central nervous system phaeohyphomycosis following intranasal inoculation of Xylohypha bantiana in cortisone-treated mice. Mycopathologia 100, 145–153 (1987). https://doi.org/10.1007/BF00437040
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DOI: https://doi.org/10.1007/BF00437040