Summary
Auxotrophic variants were obtained following UV-irradiation of Candida albicans hybrids which were heterozygous (+/+/-/-/) for various genetic markers (met, ade, his, lys). Some variants contained less DNA (per cell) than did the hybrids from which they originated; such variants were considered to arise in a process which resulted in generalized reduction in ploidy. These results provide the basis for a cyclic parasexual system (2n × 2n → 4n → 2n) for genetic analysis in this amictic diploid species.
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Whelan, W.L., Markie, D. UV-induced instability in Candida albicans hybrids. Curr Genet 9, 175–177 (1985). https://doi.org/10.1007/BF00436967
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DOI: https://doi.org/10.1007/BF00436967