, Volume 134, Issue 2, pp 75–82 | Cite as

Candida biotypes in patients with oral leukoplakia and lichen planus

Candida bio types in leukoplakia and lichen planus
  • Verónica Lipperheide
  • Guillermo Quindós
  • Yolanda Jiménez
  • José Pontón
  • José Vicente Bagán-Sebastián
  • José Manuel Aguirre
Human and Animal Mycology


Prevalence of yeasts in 35 leukoplakia and 34 oral lichen planus patients was compared with that observed in persons without oral diseases. Serotype and morphotype were determined on Candida albicans isolates. Yeasts were isolated from the oral cavity specimens of 43.7% of the patients. C. albicans (serotype A) was the predominant species (76% in leukoplakia, 88.2% in lichen planus and 60.8% in healthy persons). Sixteen morphotypes were encountered on malt extract agar, being 732, 733, 734, 753 and 754 the most frequently found. Morphotypes SP1N and SP1Y were the most common on Sabouraud-trypheniltetrazolium agar (68.4% of the isolates from leukoplakia and 73.3% from lichen planus, but only 46.6% of the isolates from healthy oral mucosa showed SP1N morphotype). Presence of oral lesions was associated with a marked reduction in the yeast species and C. albicans biotypes, suggesting that C. albicans and particularly some of its biotypes, show a high potential of adaptation to the changes associated with the development of oral leukoplakia and lichen planus.

Key words

Candida leukoplakia lichen planus biotypes 


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Verónica Lipperheide
    • 1
  • Guillermo Quindós
    • 1
  • Yolanda Jiménez
    • 2
  • José Pontón
    • 1
  • José Vicente Bagán-Sebastián
    • 2
  • José Manuel Aguirre
    • 3
  1. 1.Departamento de Inmunología, Microbiología y Parasitologia, Facultad de Medicina y OdontologiaUniversidad del País Vasco (UPV-EHU)BilbaoSpain
  2. 2.Departamento de Medicina Bucal, Facultad de Medicina y OdontologiaUniversidad de ValenciaValenciaSpain
  3. 3.Departamento de Estomatología, Facultad de Medicina y OdontologiaUniversidad del País VascoBilbaoSpain

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