Abstract
Antifungal agents alter the function and morphology of Candida cell membranes and cell walls. We observed that brief (30 minute) exposure to either amphotericin B or clotrimazole inhibited the agglutination of Candida blastoconidia by murine bronchoalveolar lavage fluid. This inhibition required continuous drug presence. Neither amphotericin nor clotrimazole inhibited Candida agglutination by concanavalin A or pooled human serum. These results demonstrate that antifungal drugs can produce rapid changes in the surface characteristics of some fungi.
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Lutz, J.C., Nugent, K.M. Interaction between Candida agglutinins and antifungal agents. Mycopathologia 99, 21–24 (1987). https://doi.org/10.1007/BF00436676
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DOI: https://doi.org/10.1007/BF00436676