Mycopathologia

, Volume 112, Issue 3, pp 147–155 | Cite as

Mycotic infection and the pediatric surgeon

  • Hagith Nagar
Article
  • 17 Downloads

Abstract

The incidence of major fungal infection in recent years has paralleled increasing use of immunosuppressive drugs, broad spectrum antibiotics and implantable catheters and prostheses. The pediatric surgeon encounters fungi as agents of perioperative infection and anatomic disease requiring surgical intervention. Clinical mycology is increasingly challenged by a wide spectrum of unfamiliar fungi, fungal infections and antimycotic drugs. An overview of the expanding role of surgical mycosis in children is presented.

Key words

Fungal infection surgery pediatrics 

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References

  1. 1.
    Predaza MA. Mycotic infections at autopsy. A comparative study in two university hospitals. Am J Clin Path 1969; 51: 470–6.Google Scholar
  2. 2.
    Rose HD, Varkey B. Mycotic infection in the hospitalized adult: A study of 123 patients. Medicine 1975; 54: 499–507.Google Scholar
  3. 3.
    Burchard KW, Minor LB, Slotman GJ, Gann DS. Fungal sepsis in surgical patients. Arch Surg 1983; 217–21.Google Scholar
  4. 4.
    Hart PD, Russell E, Jr, Remington JS. The compromised host and infection. II. Deep fungal infection. J Infect Dis 1969; 120: 169–91.Google Scholar
  5. 5.
    Eras P, Goldstein MJ, Sherlock P. Candida infection of the gastrointestinal tract. Medicine 1972; 51: 367–79.Google Scholar
  6. 6.
    Smith JMB. Mycoses of the alimentary tract. Gut 1969; 10: 1035–40.Google Scholar
  7. 7.
    Solomkin JS, Flohr AM, Simmons RC. Indications for therapy for fungemia in postoperative patients. Arch Surg 1982; 117: 1272–5.Google Scholar
  8. 8.
    Borg I, Hejjkenskjold F, Nelehn B, et al. Massive growth of yeasts in resected stomach. Gut 1966; 1: 244–9.Google Scholar
  9. 9.
    Tustin AW, Kaiser AB, Bradsher RW, Herrington L. Unusual fungal infections following jejunoileal bipass. Arch Intern Med 1980; 140: 643–5.Google Scholar
  10. 10.
    Solomkin JS, Flohr AB, Quie PG, et al. The role of Candida in intraperitoneal infections. Surgery 1980; 88: 524–30.Google Scholar
  11. 11.
    Lewis JH, Patel HR, Zimmerman HJ. The spectrum of hepatic candidiasis. Hepatology 1982; 2: 479–87.Google Scholar
  12. 12.
    Wald BR, Ortega JA, Ross W. Candidal splenic abscess complicating acute leukemia of childhood treated by splenectomy. Pediatrics 1981; 67: 296–9.Google Scholar
  13. 13.
    Richter JM, Jacoby GA, Schapiro H. Pancreatic abscess due to Candida albicans. Ann Intern Med 1982; 97: 221–2.Google Scholar
  14. 14.
    Uflacker R, Wholey MH, Amaral NM, et al. Parasitic and mycotic causes of biliary obstruction. Gastrointest Radiol 1982; 7: 173–9.Google Scholar
  15. 15.
    Chen C, Chang P, Chen C. Refractory cholangitis after Kasai's operation caused by candidiasis: a case report. J Pediatr Surg 1986; 18: 736–7.Google Scholar
  16. 16.
    Young RC, Bennett JE, Vogel CL, et al. Aspergillosis. The spectrum of the disease in 98 patients. Medicine 1970; 49: 147–73.Google Scholar
  17. 17.
    Raaf JH, Donahoe PK, Truman JT, Robboy SJ. Aspergillus-induced small bowel obstruction in a leukemia newborn. Surgery 1977; 81: 111–3.Google Scholar
  18. 18.
    Meyer RD, Armstrong D. Mucormycosis: changing status. CRC Crit Rev Clin Lab Sci 1973; 4: 421–51.Google Scholar
  19. 19.
    McBride RA, Corson JM, Dammin GJ. Mucormycosis. Two cases of disseminated disease with cultural identification of Rhizopus; review of literature. Am J Med 1960; 28: 832–46.Google Scholar
  20. 20.
    Michalak DM, Cooney DR, Rhodes RH, Telander RL, Kleinberg F. Gastrointestinal mucormycosis in infants and children: a cause of gangrenous intestinal cellulitis and perforation. J Pediatr Surg 1980; 15: 320–4.Google Scholar
  21. 21.
    Mullens JE, Leers WD, Smith GW. Phycomycosis involving the intestine and anterior abdominal wall. A case report. Ann Surg 1970; 171: 303–8.Google Scholar
  22. 22.
    Levin SE, Isaacson C. Spontaneous perforation of the colon in the newborn. Arch Dis Child 1960; 35: 378–82.Google Scholar
  23. 23.
    Gatling RR. Gastric mucormycosis in a newborn infant. Arch Pathol 1960; 67: 249.Google Scholar
  24. 24.
    Neame P, Rayner D. Mucormycosis. Arch Pathol 1960; 70: 261–8.Google Scholar
  25. 25.
    Isaacson C, Lebin SE. Gastrointestinal myucormycosis in infancy. S Afr Med J 1961; 35: 581–4.Google Scholar
  26. 26.
    Shull HJ. Human histoplasmosis. Disease with protean manifestations, often with digestive system involvement. Gastroenterology 1953; 25: 582–95.Google Scholar
  27. 27.
    Goodwin RA, Shapiro JL, Thurman GH, Thurman SS, DesPrez RM. Disseminated histoplasmosis: Clinical and pathologic correlations. Medicine 1959; 59: 1–33.Google Scholar
  28. 28.
    Mir-Madjlessi SH, Farmer RG, Hawk WA. Granulomatous hepatitis. A review of 50 cases. Am J Gastroenterol 1973; 60: 122–34.Google Scholar
  29. 29.
    Cockshott WP, Lucas AO. Histoplasmosis dubosii. Q J Med 1964; 133: 223–38.Google Scholar
  30. 30.
    Restrepo A, Robeldo M, Gutierrey F, et al. Paracoccidiomycosis (South American blastomycosis). Am J Trop Med Hyg 1970; 19: 68–76.Google Scholar
  31. 31.
    Kozinn PJ, Taschdjian CL, Wiener H, Dragutsky D, Minsky A. Neonatal candidiasis. Pediat Clin N Amer 1958; 5: 803–15.Google Scholar
  32. 32.
    Andersen NA, Sage DN, Spaulding EH. Oral moniliasis in newborn infants. Am J Dis Child 1944; 67: 450–5.Google Scholar
  33. 33.
    Rotrosen D, Gibson TR, Edwards JE, Jr. Adherence of Candida species to intravenous catheters. J Inf Dis 1983; 147: 594.Google Scholar
  34. 34.
    Pasternak BM, Samson R, Karp MD. Fungal infection of a vascular prosthesis. Surgery 1979; 85: 586–8.Google Scholar
  35. 35.
    Keller MA, Sellers BB, Melish ME, Kaplan GW, Miller KE, Mendoza SA. Systemic candidiasis in infants. Am J Dis Child 1977; 131: 1260–3.Google Scholar
  36. 36.
    Deitch EA, Marini JJ, Huseby JS. Suppurative Candida phlebitis of a peripheral vein. J Trauma 1980; 20: 618–20.Google Scholar
  37. 37.
    Joachim H, Polayes S. Subacute endocarditis and systemic mycosis (monilia). JAMA 1940; 115: 205.Google Scholar
  38. 38.
    McLoed R, Remington JS. Postoperative fungal endocarditis. In: Duma RJ (ed). Infections of prosthetic heart valves and vascular grafts. Prevention, diagnosis and treatment. Baltimore: University Park Press, 1977, pp. 163; 211.Google Scholar
  39. 39.
    Rubin RH, Moellering RC. Clinical, microbiologic and therapeutic aspects of purulent endocarditis. Am J Med 1975; 59: 68–78.Google Scholar
  40. 40.
    Rubinstein E, Noriega ER, Simberkoff MS, Holzman R, Rahal JJ, Jr. Fungal endocarditis: Analysis of 24 cases and review of the literature. Medicine 1975; 54: 331–44.Google Scholar
  41. 41.
    Walsh TJ, Hutchins GM. Postoperative candida infections of the heart in children: clinico-pathologic study of a continuing problem of diagnosis and therapy. J Pediatr Surg 1980; 15: 325–31.Google Scholar
  42. 42.
    Wiley EL, Hutchins GM. Superior vana cava syndrome secondary to Candida thrombophlebitis complicating parenteral hyperalimentation. J Pediatr 1977; 91; 977–9.Google Scholar
  43. 43.
    Foker J, Bass J, Thompson T, et al. Management of intracardiac fungal masses in premature infants. J Thorac Cardiovasc Surg 1984; 87: 244–50.Google Scholar
  44. 44.
    Barst RJ, Prince AS, Neu H. Aspergillus endocarditis in children: Case report and review of the literature. Pediatrics 1981; 68: 73–8.Google Scholar
  45. 45.
    Luke JL, Bolande RP, Grass S. Generalized aspergillosis and aspergillus endocarditis in infancy. Pediatrics 1963; 31: 115–22.Google Scholar
  46. 46.
    Goodwin RA, Loyd JE, DesPrez RM. Histoplasmosis in normal hosts. Medicine 1981; 60: 231–66.Google Scholar
  47. 47.
    Goodwin RA, Nickell JA, DesPrez RM. Mediastinal fibrosis complicating healed primary histoplasmosis and tuberculosis. Medicine 1972; 51: 227–46.Google Scholar
  48. 48.
    Dennis D, Miller MJ, Peterson CG. Candida septicemia. Surg Gynecol Obstet 1964; 119: 520–30.Google Scholar
  49. 49.
    Wiseman NE, Reed MH. Bronchopulmonary arterial malformation occurring in Aspergillus lung infection complicating chronic granulomatous disease. J Pediatr Surg 1981; 16: 457–60.Google Scholar
  50. 50.
    Varkey B, Rose HD. Pulmonary aspergilloma. A rational approach to treatment. Am J Med 1976; 61: 626–31.Google Scholar
  51. 51.
    Shamberger RC, Weinstein HJ, Grier HE, Levey RH. The surgical management of fungal pulmonary infections in children with acute myelogenous leukemia. J Pediatr Surg 1985; 20: 840–4.Google Scholar
  52. 52.
    Fisher J, Mayhall G, Duma R, et al. Fungus ball of the urinary tract. South Med J 1979; 72: 1281–4.Google Scholar
  53. 53.
    Littman ML, Walter JE. Cryptococcosis: current status. Am J Med 1968; 45: 922–32.Google Scholar
  54. 54.
    Michigan S. Genitourinary fungal infections. J Urol 1976; 116: 390–7.Google Scholar
  55. 55.
    Smith H, Congdon P. Neonatal systemic candidiasis. Arch Dis Child 1985; 4: 365–9.Google Scholar
  56. 56.
    Witorsch P, Utz JP. North American blastomycosis: a study of 40 patients. Medicine 1968; 47: 169–200.Google Scholar
  57. 57.
    Duttera MV, Osterhout S. North American blastomycosis: a survey of 63 cases. South Med J 1969; 62: 295–301.Google Scholar
  58. 58.
    Bayer AS, Yoshikawa TT, Galpin J, Guze LB. Unusual syndromes of coccidioidomycosis: Diagnostic and therapeutic considerations. Medicine 1976; 55: 131–52.Google Scholar
  59. 59.
    Salyer WR, Salyer DC. Involvement of the kidney and prostate in cryptococcosis. J Urol 1973; 109: 695–8.Google Scholar
  60. 60.
    Schwartz J. Mycotic prostatitis. Urology 1982; 19: 1–5.Google Scholar
  61. 61.
    Simpson MB, Jr, Merz WG, Kurlinski JP, et al. Opportunistic mycotic osteomyelitis: Bone infections due to Aspergillus and Candida species. Medicine 1977; 56: 475–82.Google Scholar
  62. 62.
    Yap S, Ravitch MM, Pataki KI. En bloc chest wall resection for candidal costochondritis in a drug addict. Ann Thorac Surg 1981; 31: 182–7.Google Scholar
  63. 63.
    Buscino L, Iannaccone G, DelPrincipe D, Lucarelle S, Cardi E, Rizza E. Disseminated arthritis and osteitis by Candida albicans in a 2-month-old infant receiving parenteral nutrition. Acta Pediatr Scand 1977; 66: 393–5.Google Scholar
  64. 64.
    Mawk JR, Erickson DL, Chow SN, et al. Aspergillus infections of the lumbar disc spaces: Report of 3 cases. J Neurosurg 1983; 58: 270–4.Google Scholar
  65. 65.
    Byrd BF, Weiner MH, McGee ZA. Aspergillus spinal epidural abscess. JAMA 1982; 248: 3138–9.Google Scholar
  66. 66.
    Kafka JA, Cantanzaro A. Disseminated coccidioidomycosis in children. J Pediatr 1981; 98: 355–61.Google Scholar
  67. 67.
    Bayer AS, Scott VJ, Guze LB. Fungal arthritis III. Sportrichal arthritis. Semin Arthrit Rheum 1979; 9: 66–74.Google Scholar
  68. 68.
    Lynch PJ, Voorhees JJ, Harrell ER. Systemic sporotrichosis. Ann Intern Med 1970; 73: 23–30.Google Scholar
  69. 69.
    Tight RR, Bartlett MS. Actinomycetoma in the United States. Rev Infect Dis 1981; 3: 1139–50.Google Scholar
  70. 70.
    Gartenberg C, Bottone EJ, Keusch GT, et al. Hospital acquired mucormycosis (Rhizopus rhizopodiformis) of skin and subcutaneous tissue. N Engl J Med 1978; 299: 1115–8.Google Scholar
  71. 71.
    Bruck HM, Nash G, Foley FD, et al. Opportunistic fungal infection of the burn wound with Phycomycetes and Aspergillus. Arch Surg 1971; 102: 476–82.Google Scholar
  72. 72.
    Wilson CB, Siber GR, O'Brien TF, et al. Phycomycotic gangrenous cellulitis. A report of two cases and a review of the literature. Arch Surg 1976; 111: 532–8.Google Scholar
  73. 73.
    Golladay ES, Baker SB. Invasive aspergillosis in children. J Pediatr Surg 1987; 22: 504–5.Google Scholar
  74. 74.
    Laskey WK. Blastomycosis in children. Pediatrics 1980; 65: 111–4.Google Scholar
  75. 75.
    Cohen R. Coccidioidomycosis: case report in children. Arch Pediat 1949; 66: 241–3.Google Scholar
  76. 76.
    Rao TV, Tao KS, Satyanarayana CV, Pradesh A. Primary cutaneous cryptococcal granuloma in a child. J Pediatr Surg 1976; 11: 267–8.Google Scholar
  77. 77.
    Powell KE, Taylor A, Phillips BJ, et al. Chronic sporotrichosis in forestry workers. JAMA 1978; 240: 232–5.Google Scholar
  78. 78.
    Chandler JW, Kriel RL, Tosh FE. Childhood sporotrichosis. Am J Dis Child 1968; 115: 368–72.Google Scholar
  79. 79.
    Dahl BA, Silberfarb PM, Sarosi GA, Weeks RJ, Tosh FE. Sporotrichosis in children. JAMA 1971; 215: 1980–2.Google Scholar
  80. 80.
    Francois J, Russelaere M. Occulomycoses. Springfield, Mass: Charles C. Thomas, 1972.Google Scholar
  81. 81.
    Palmer EA. Endogenous Candida endophthalmitis in infants. Am J Ophthal 1980; 89: 388–95.Google Scholar
  82. 82.
    Heath P. Massive separation of retina in full-term infants and juveniles. JAMA 1950; 144: 1148–9.Google Scholar
  83. 83.
    Alexander PB, Coodley EL. Disseminated coccidioidomycosis with intraocular involvement. Am J Ophthal 1967; 64: 283–9.Google Scholar
  84. 84.
    Neuhauser EBD, Tucker A. The roentgen changes produced by diffuse torulosis in the newborn. Amer J Roentgenol 1948; 59: 805–10.Google Scholar
  85. 85.
    Romett JL, Newman RK. Aspergillosis of the nose and paranasal sinuses. Laryngoscope 1982; 92: 764–6.Google Scholar
  86. 86.
    Meyer RD, Rosen P, Armstrong D. Phycomyosis complicating leukemia and lymphoma. Ann Intern Med 1972; 77: 871–9.Google Scholar
  87. 87.
    Drugs for treatment of systemic fungal infection. Med Lett Drugs Ther 1986; 28: 41–4.Google Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Hagith Nagar
    • 1
  1. 1.Department of Pediatric SurgeryTel-Aviv Medical CenterTel-AvivIsrael

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