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Mycopathologia

, Volume 84, Issue 2–3, pp 107–113 | Cite as

Studies on defense mechanisms against Candida albicans infection in congenitally athymicnude (nu/nu) mice

  • Hiroshi Tabeta
  • Yuzuru Mikami
  • Fumihiko Abe
  • Yuuta Ommura
  • Tadashi Arai
Article

Abstract

The defense mechanisms against Candida albicans infection were studied by using a mouse thigh lesion model in congenitally athymic nude (nu/nu) mice and their normal littermates (nu/+). Nu/nu mice were more resistant to C. albicans infection than nu/+ mice judging from the course of the thigh lesion, the results of CFUs (colony-forming units) of C. albicans in the lesion, and histopathological observations. Histopathological and serological studies revealed that granulocytic cellular infiltration was predominant, and there were few indications of development of cell-mediated immunity to protect Candida infection in Candida-infected nu/nu and nu/+ mice. These results confirmed that lower susceptibility of nu/nu mice to C. albicans infection as compared with nu/ + mice was due to accelerated non-specific defense mechanisms in nu/nu mice, and that cell-mediated or humoral immunity played a minor role in the defense against Candida infection in this experimental model.

Furthermore, treatment with high titer of rabbit anti-C. albicans serum was effective to control the number of Candida cells in thigh lesions of BALB/c mice.

Above experimental results seem to clearly indicate the great variability of defense manifestation according to the experimental model exployed.

Keywords

Candida Defense Mechanism Candida Albicans Humoral Immunity Candida Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Dr W. Junk Publishers 1984

Authors and Affiliations

  • Hiroshi Tabeta
    • 1
  • Yuzuru Mikami
    • 1
  • Fumihiko Abe
    • 2
  • Yuuta Ommura
    • 2
  • Tadashi Arai
    • 1
  1. 1.Research Institute for ChemobiodynamicsChiba UniversityChibaJapan
  2. 2.Second Department of PathologyHokkaido University School of MedicineSapporoJapan

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