Abstract
The viability of Candida albicans was tested at various intervals in the lungs of rats following single intratracheal inoculation of the yeast cells. Most of the inoculated cells were cleared from lungs within 48 hr after exposure. Clearance was enhanced in lungs exposed to metal-coated fly ash than in those exposed to native fly ash. The validity of these studies was verified in vitro using peritoneal macrophages of mice exposed in vivo to native and metal-coated fly ash. An increase in phagocytic and intracellular killing of macrophages harvested from animals exposed to native or metal-coated fly ash was observed.
Similar content being viewed by others
References
Fisher GL, Wilson FD. The effect of coal fly ash and silica inhalation on macrophage function and progenitors. J Reticuloendo Soc 1980; 27: 513–24.
Zarkower A, Eskew ML, Scheuchenzuber WJ, Graham JA. Effects of fly ash inhalation on murine immune function. Changes in macrophage mediated activities. Environ Res 1982; 29: 83–9.
Shami SG, Salbaugh SA, Hahn FF, Griffith WC, Hobbs CH. Cytokinetic and morphological changes in the lungs and lungs associated lymph nodes of rats after inhalation of fly ash. Environ Res 1984; 35: 373–93.
Kaw JL, Khanna AK. Development of silicotic lesions in the lungs of rats pre-exposed to coal fly ash. Brit J Industr Med 1988; 45: 312–9.
Bice DE, Hahn FF, Benson J, Carpenter RL, Hobbs CH. Comparative lung immunotoxicity of inhaled quartz and coal combustion fly ash. Environ Res 1987; 43: 374–89.
Dogra S, Khanna AK, Kaw JL. Alterations in the pulmonary and systemic immune response in rats exposed to coal fly ash. Immunopharmacol 1995; 29: 103–9.
Byers PD, King EJ. Experimental and infective pneumoconiosis. Lab Invest 1959; 8: 647–64.
Zaidi SH. Simple and infective pneumoconiosis, PhD Thesis. London University, London, England, 1954.
Aheam GD. Medically important yeasts. Annu Rev Microbiol 1978; 32: 59–68.
Fels AOS, Cohn ZA. The alveolar macrophages. J Appl Physiol 1986; 60: 353–69.
Bowden DH. The alveolar macrophage and its role in toxicology. CRC Crit Rev Toxicol 1973; 2: 95–124.
Nathan CF, Murray HW, Cohn ZA. The macrophage as an effector cell. N Engl J Med 1980; 303: 622–6.
Towes GB, Vial WC, Dunn MM, Guzzetta P, Nunez GP, Stastny P, Lipcomb MF. The accessory cell function of human alveolar macrophages in specific T-cell proliferation. J Immunol 1984; 132: 181–6.
Natusch DFS, Wallace JR, Evans CA, Jr. Toxic trace elements: preferential concentration in respirable particles. Science 1974; 183: 202–4.
Bajpai R, Waseem M, Kaw JL. Pulmonary response to cadmium and nickel coated fly ash. J Environ Pathol Toxicol & Oncol 1974; 13: 251–7.
Aranyi C, Miller FJ, Andres S, Ehrlich R, Fenters J, Garden DE, Waters MD. Cytotoxicity to alveolar macrophages of trace metal adsorbed on fly ash. Environ Res 1979; 20: 14–23.
Kaw JL, Tilkes F, Beck EG. Reaction of cells cultured in vitro to different asbestos dusts of equal surface area but different fibre length. Brit J Exp Path 1982; 63: 109–15.
Sawyer RT. Experimental pulmonary candidiasis, Mycopathologia 1990; 109: 99–109.
Salim R, Komaid A. In vivo determination of phagocytic indices and candidacidial activities of Candida species by rat peritoneal macrophages. Mycopathologia 1986; 95: 177–23.
Sasada M, Johnston RB, Jr. Macrophage microbicidal activity. Correlation between phagocytosis associated oxidative metabolism and killing of Candida by macrophages. J Exp Med 1980; 152: 85–98.
Khanna AK, Waseem M, Dogra S, Srivastava R, Kaw JL. Pulmonary response to coal fly ash: Organ weight, hematological, histological and biochemical studies. Ad Biosc 1992; 11: 1–10.
Miller K. Alterations in the surface related phenomenon of alveolar macrophages following inhalation of crocidolite, asbestos and quartz dusts. An overview. Environ Res 1979; 20: 162–82.
Donaldson K, Davis JKG, James K. Characteristics of peritoneal macrophages induced by asbestos injection. Environ Res 1982; 29: 414–24.
Arai T, Milkami Y, Yokoyama, K. Phagocytosis of Candida albicans by rabbit alveolar macrophages and guinea pig neutrophils. Sabourandia 1977; 15: 171–7.
Maiti PK, Kumar R, Monapatra LN. Candidacidal activity of mouse macrophages in vitro. Infect Immun 1980; 29: 477–82.
Beginski B, Grube R. Effect of lead, zinc and cadmium on the cytotoxic action of polymorphonuclear leucocytes on yeast cells. Zentralbl Hyg Umweltmed 1991; 191: 28–35.
Queiroz ML, Costa FF, Bincoletto C, Perlingeiro RC, Dantas DC, Cardoso MP, Almeida M. Engulfment and killing capabilities of neutrophils and phagocytic splenic function in persons occupationally exposed to lead. Int J Immunopharmacol 1994; 16: 239–44.
Author information
Authors and Affiliations
Additional information
ITRC communication No. 1922
Rights and permissions
About this article
Cite this article
Bajpai, R., Waseem, M., Dogra, S. et al. Pulmonary clearance of Candida albicans: Effect of exposure to native and metal-coated fly ash. Mycopathologia 135, 103–108 (1996). https://doi.org/10.1007/BF00436459
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00436459