Psychopharmacology

, Volume 77, Issue 1, pp 11–16 | Cite as

Hyperbaric ethanol antagonism in mice: Studies on oxygen, nitrogen, strain and sex

  • Ronald L. Alkana
  • Richard D. Malcolm
Original Investigations

Abstract

Male and female C57BL/6J and male BALBc/J mice were injected with 3.6 g/kg ethanol or saline and exposed to 1–10 atmospheres absolute (ATA) air, to 1 ATA 80% helium-20% oxygen, or to 12 ATA helium-oxygen having oxygen partial pressures between 0.5 and 18 times normal. Hyperbaric helium-oxygen significantly reduced sleep-time and increased wake-up brain ethanol concentrations in all mice tested. The degree of antagonism was not enhanced by increasing the oxygen partial pressure. Hyperbaric air increased sleep-time and decreased wake-up brain ethanol concentration in C57 mice. Hyperbaric air induced a pressure-related lethal effect beginning at 6 ATA in intoxicated BALBs. These findings demonstrate that hyperbaric ehanol antagonism extends across strains and sexes, that the degree of antagonism cannot be enhanced by increasing the oxygen partial pressure, and that air is not suitable as an antagonistic hyperbaric gas. The findings are consistent with membrane theories of anesthesia.

Key words

Ethanol Ethanol antagonists Ethanol narcosis Hyperbaric pressure Inert gas narcosis Oxygen toxicity 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Ronald L. Alkana
    • 1
  • Richard D. Malcolm
    • 1
  1. 1.Institute for Toxicology, School of PharmacyUniversity of Southern CaliforniaLos AngelesUSA

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