Summary
The pharmacokinetics of soluble oral prednisolone were studied during induction therapy in six children with acute lymphoblastic leukaemia. There was a three- to four-fold variation in the pharmacokinetics of total and free prednisolone. For total prednisolone, the mean elimination half-life was relatively short (1.37 h) and the total clearance, relatively high (15.1 ml min-1 kg-1). The mean free fraction was high (0.37).
References
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Choonara, I., Wheeldon, J., Rayner, P. et al. Pharmacokinetics of prednisolone in children with acute lymphoblastic leukaemia. Cancer Chemother. Pharmacol. 23, 392–394 (1989). https://doi.org/10.1007/BF00435843
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DOI: https://doi.org/10.1007/BF00435843