Cancer Chemotherapy and Pharmacology

, Volume 23, Issue 6, pp 392–394 | Cite as

Pharmacokinetics of prednisolone in children with acute lymphoblastic leukaemia

  • Imtiaz Choonara
  • John Wheeldon
  • Phil Rayner
  • Mike Blackburn
  • Ian Lewis
Short Communication Prednisolone, Pharmacokinetics, Leukaemia, Children


The pharmacokinetics of soluble oral prednisolone were studied during induction therapy in six children with acute lymphoblastic leukaemia. There was a three- to four-fold variation in the pharmacokinetics of total and free prednisolone. For total prednisolone, the mean elimination half-life was relatively short (1.37 h) and the total clearance, relatively high (15.1 ml min-1 kg-1). The mean free fraction was high (0.37).


Cancer Research Prednisolone Lymphoblastic Leukaemia Induction Therapy Acute Lymphoblastic Leukaemia 
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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Imtiaz Choonara
    • 1
  • John Wheeldon
    • 1
  • Phil Rayner
    • 1
  • Mike Blackburn
    • 1
  • Ian Lewis
    • 1
  1. 1.Department of Paediatrics and Child HealthSt. James's University HospitalLeedsUK

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