Abstract
Insulin binding kinetics in the liver were studied in non insulin dependent (Type 2) diabetic patients, by i.v. bolus administration of 123I-insulin. Eight Type 2 diabetic patients were compared with six male volunteers. Uptake of 123I-insulin by liver and kidneys was measured by dynamic scintigraphy with a gamma camera during 30 min. Images of liver and kidneys appeared within 2–3 min after administration of 123I-insulin at a dose of 1 mCi (37 MBq). Peak radioactivity for the liver was found 7.5±0.2 and 6.9±0.3 min after injection for the healthy and the diabetic subjects, respectively (N.S.). The percentage 123I-insulin hepatic uptake was not significantly different for the diabetic and the healthy subjects.
Although a large variation exists for maximal uptake of radioactivity within both groups, the data suggest that binding differences in the liver in Type 2 diabetic patients, as compared to healthy subjects, may not account for hepatic insulin resistance.
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References
Bourdeau JE, Chen ERY, Carone FA (1973) Insulin uptake in the renal proximal tubule. Am J Physiol225:1399–1407
Chamberlain MJ, Stimmler L (1967) The renal handling of insulin. J Clin Invest 46:911–919
De Fronzo RA, Simsonson D, Ferrannini E (1982) Hepatic and peripheral insulin resistance: a common feature of type 2 (noninsulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia 23:313–319
Hachiya HL, Treves ST, Kuhn CR, Sodoyez JC, Sodoyez-Goffaux F (1987) Altered insulin distribution and metabolism in type 1 diabetics assessed by [123I]insulin scanning. J Clin Endocrinol Metab 64:801–808
Kolterman OG, Gray RS, Griffin J, Burstein P, Insel J, Scarlett JA, Olefsky JM (1981) Receptor and postreceptor defects contribute to the insulin resistance in non-insulin-dependent diabetes mellitus. J Clin Invest 68:957–969
Kolterman OG, Scarlett JA, Olefsky JM (1982) Insulin resistance in non-insulin-dependent, type 2 diabetes mellitus. Clin Endocrinol Metab 11:363–388
Olefsky JM (1981) Insulin resistance and insulin action. An in vitro and in vivo perspective. Diabetes 30:148–162
Peavy DE, Abram JD, Frank B, Duckworth WC (1984) Receptor binding and biological activity of specifically labeled 125I-and 127I-monoiodoinsulin isomers in isolated rat adipocytes. Endocrinology 114:1818–1824
Revers RR, Flink R, Griffin J, Olefsky JM, Kolterman OG (1984) Influence of hyperglycaemia on insulin's in vivo effects in type 2 diabetes. J Clin Invest 73:664–672
Rubenstein AH, Spitz I (1968) Role of the kidney in insulin metabolism and excretion. Diabetes 17:161–167
Sodoyez JC, Sodoyez-Goffaux F, Guillaume M, Merchie G (1983) 123I-insulin metabolism in normal rats and humans: external detection by a scintillation camera. Science 219:865–867
Sodoyez JC, Sodoyez-Goffaux F, Jacquemin R, Fallais C (1984) Imaging of 123I-insulin interaction with its receptors in normal human volunteers: lack of effect on blood glucose concentration and low radiotoxicity. J Biophys Med Nucl 8:281–285
Sodoyez JC, Sodoyez-Goffaux F, von Frenckell R, De Vos CJ, Treves S, Kahn CR (1985) Differing effects of antiinsulin serum and antiinsulin recpetor serum on 123I-insulin metabolism in rats. J Clin Invest 75:1455–1462
Winer BJ (1971) Statistical Principles in Experimental Design, 2nd edn, pp. 796–809. McGraw-Hill Kogakuska Ltd., Tokyo
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Oolbekkink, M., Heine, R.J., den Hollander, W. et al. Hepatic 123I-insulin binding kinetics in non-insulin-dependent (Type 2) diabetic patients after i.v. bolus administration. Eur J Nucl Med 15, 292–295 (1989). https://doi.org/10.1007/BF00435468
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DOI: https://doi.org/10.1007/BF00435468