Abstract
Hexakis 99mTc-tertiary butyl isonitrile (99mTc-TBI) was studied as a cardiac perfusion imaging agent in nine dogs with partial occlusion of the LAD. Thirty min after applying the stenosis, 99mTc-TBI was injected into the right atrium (RA) in five dogs and left atrium (LA) in four dogs. Normal and ischemic zone regional myocardial 99mTc-TBI activites were monitored continuously for 4 h. Dogs with LA injections had minimal and equivalent 4 h fractional clearance from the normal and ischemic zones. Dogs with RA injections had minimal, but significantly lower 4 h fractional 99mTc clearances in the ischemic zone (0.08±0.08) compared to the normal zone (0.16±0.07, P<0.05). The delayed ischemic zone clearance is probably due to the high initial lung uptake observed after RA injection. Despite the differences in clearance, this minimal amount of redistribution could not be detected on gamma camera images. The minimal myocardial washout and redistribution, and the 140 keV gamma make 99mTc-TBI a promising cardiac perfusion imaging agent.
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Gerundini P, Annarita S, Gilardi MC, Margonato A, Vicedomini G, Zecca L, Hirth W, Libson K, Bhatia JC, Fazio F, Deutsch E (1986) Evaluation in dogs and humans of three potential technetium-99m myocardial perfusion agents. J Nucl Med 27:409–416
Holman BL (1985) Nuclear cardiology in heart disease, 2nd Ed. In: Braunwald E (ed) Saunders, Philadelphia, pp 409–416
Holman BL, Jones AG, Lister-James J, Davison A, Abrams MJ, Kirshendaum JM, Tumeh SS, English RJ (1984) A new Tc-99m-labeled myocardial imaging agent, hexakis (t-butyl-isonitrile) technetium (I) [[99mTc]TBI]: Initial experience in humans. J Nucl Med 27:1350–1355
Holman BL, Campbell CA, Lister-James J, Jones AG, Davison A, Kloner RA (1986) Effect of reperfusion and hyperemia on the myocardial distribution of technetium-99m t-butylisonitrile. J Nucl Med 27:1172–1177
Mousa SA, Stevens SJ, Williams SJ (1986) Regional distribution of Tc-99m hexakis aliphatic isonitriles in ischemic heart with and without reperfusion. J Nucl Med 27:994
Okada RD, Leppo JA, Strauss HW, Boucher CA, Pohost GM (1982a) Mechanisms and time course for the disappearance of thallium-201 defects at rest in dogs. Am J Cardiol 49:699–706
Okada RD, Daggett WM, Jacobs ML, Leppo J, Strauss HW, Newell JB, Moore R, Boucher CA, O'Keefe D, Pohost GM (1982b) Thallium-201 kinetics in non-ischemic canine myocardium. Circulation 65:70–77
Okada RD, Boucher CA, Williams SJ, McKusick K, Dragotakes D, Garneau J (1986) Cardiac imaging and myocardial kinetics of technetium tertiary butyl isonitrile during dipyridamole induced hypermia. J Am Coll Cardiol 7: 102A
Pohost GM, Budinger TF (1986) Thallium “redistribution”: An explanation. J Nucl Med 27:996
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Dr. Okada is an Established Investigator of the American Heart Association
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Williams, S.J., Dragotakos, D.L. & Okada, R.D. Kinetics of Tc-99m hexakis t-butyl isonitrile in normal and ischemic canine myocardium. Eur J Nucl Med 15, 287–291 (1989). https://doi.org/10.1007/BF00435467
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DOI: https://doi.org/10.1007/BF00435467