Psychopharmacology

, Volume 70, Issue 2, pp 137–143 | Cite as

Sensory and associative effects of LSD on classical appetitive conditioning of the rabbit jaw movement response

  • I. Gormezano
  • John A. Harvey
  • Ellen Aycock
Original Investigations

Abstract

Three experiments were conducted to determine the effects of LSD (30 nmol/kg) in classical appetitive conditioning of the rabbit jaw movement response (JMR). In experiment 1, LSD significantly enhanced the acquisition of conditioned responses (CRs). The performance of control groups receiving unpaired presentations of the conditioned stimulus (CS) and unconditioned stimulus (UCS) demonstrated that LSD's enhancing effect on conditioning could not be attributed to an elevation in baseline responding, sensitization, or pseudoconditioning. Accordingly, experiments 2 and 3 were conducted to determine whether LSD's enhancement of conditioning could have arisen from its altering the sensory processing of either the CS or UCS, or botj. In experiment 2, LSD was found to have no significant effect on the functions relating UCS magnitude to the frequency, amplitude, or number of sinusoidal peaks comprising each unconditioned response (UCR). In contrast, experiment 3 revealed that LSD significantly enhanced the frequency of CRs to an extended range of CS intensities and lowered the CS intensity threshold. It was concluded that the enhancing effect of LSD on the acquisition of CRs is attributable, at least in part, to the drug's enhancement of the sensory processing of the CS.

Key words

LSD Classical conditioning Rabbit Learning Sensory processing 

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References

  1. Burian H, Fleming W, Featherstone R (1958) Electroretinographic effects of LSD-25, brom-LSD, and LSM (lysergic acid morpholide). Fed Proc 17:355Google Scholar
  2. Cegavske CF, Thompson RF, Patterson MM, Gormezano I (1976) Mechanisms of efferent neuronal control of the reflex nictitating membrane response in rabbit (Oryctolagus cuniculus). J Comp Physiol Psychol 90:411–423Google Scholar
  3. Doty RW (1968) Alimentary canal: motility. In: Handbook of Physiology. American Physiological Society. Washington, DC, pp 1861–1902Google Scholar
  4. Gimpl MP, Gormezano I, Harvey JA (1978) Effects of LSD on learning as measured by classical conditioning of the rabbit nictitating membrane response. J Pharmacol Exp Ther 208:330–334Google Scholar
  5. Gormezano I (1966) Classical conditioning. In: Sidowski JB (ed) Experimental methods and instrumentation in psychology. McGraw-Hill, New York, pp 385–420Google Scholar
  6. Gormezano I (1972) Investigations of defense and reward conditioning in the rabbit. In: Black, AH, Prokasy WF, (eds) Classical conditioning II: Current research and theory. Appleton-Century-Crofts, New York, pp 151–181Google Scholar
  7. Gormezano I, Harvey JA (1978) Analysis of hallucinogens by means of Pavlovian conditioning. In: Stillman, R, Willette R, (eds) Psychopharmacology of hallucinogens. Pergamon Press, New York, pp 207–219Google Scholar
  8. Gormezano I, Harvey JA (1980) Sensory and associative effects of LSD in classical conditioning of the rabbit (Oryctolagus cuniculus) nictitating membrane response. J Comp Physiol (in press)Google Scholar
  9. Gormezano I, Kehoe EJ (1975) Classical conditioning: Some methodological conceptual issues. In: Estes WK (ed) Handbook of learning and cognitive processes. Conditioning and behavior theory, Vol. 2. Lawrence Erlbaum Associates, New Jersey, pp 143–179Google Scholar
  10. Gormezano I, Moore JW (1969) Classical conditioning. In: Marx MH (ed) Learning: Processes. MacMillan, New York, pp 121–203Google Scholar
  11. Grice GR (1968) Stimulus intensity and response evocation. Psychol Rev 75:359–374Google Scholar
  12. Grice GR (1972) Conditioning and a decision theory of response evocation. In: Bower GH (ed) Psychology of learning and motivation. Academic Press, New YorkGoogle Scholar
  13. Grice GR, Hunter JJ (1964) Stimulus intensity effects depend upon the type of experimental design. Psychol Rev 71:247–256Google Scholar
  14. Harvey JA, Gimpl MP, Gormezano I (1980) Effect of haloperidol and pimozide on learning as measured by classical conditioning of the rabbit nictitating membrane response. J Pharmacol Exp Ther (in press)Google Scholar
  15. Hull CL (1943) Principles of behavior. Appleton-Century-Crofts, New YorkGoogle Scholar
  16. Hull CL (1949) Stimulus intensity dynamism (V) and stimulus generalization. Psychol Rev 56:67–76Google Scholar
  17. Hull CL (1952) A behavior system. Yale University Press, New HavenGoogle Scholar
  18. Logan FA (1956) A note on stimulus intensity dynamism (V). Psychol Rev 63:63–73Google Scholar
  19. Mitchell DS, Gormezano I (1970) Water deprivation effects in classical appetitive conditioning of the rabbit's jaw movement response. Learn Motiv 1:199–206Google Scholar
  20. Moore JW, Goodell NA, Solomon PR (1976) Central cholinergic blockade by scopolamine and habituation, classical conditioning, and latent inhibition of the rabbit's nictitating membrane response. Physiol Psychol 4:395–399Google Scholar
  21. Perkins CC, Jr (1953) The relation between conditioned stimulus intensity and response strength. J Exp Psychol 46:225–231Google Scholar
  22. Poulos CX, Sheafor PJ, Gormezano I (1971) Classical appetitive conditioning of the rabbit's (Oryctolagus cuniculus) jaw-movement response with a single-alternation schedule. J Comp Physiol Psychol 75:231–238Google Scholar
  23. Purpura DP (1956) Electrophysiological analysis of psychotogenic drug action. I. Effect of LSD on specific afferent systems in the cat. Arch Neurol Psychiatry 75:122–131Google Scholar
  24. Razran G (1957) The dominance-contiguity theory of the acquisition of classical conditioning. Psychol Bull 54:1–46Google Scholar
  25. Scavio MJ, Gormezano I (1974) CS intensity effects on rabbit nictitating membrane conditioning, extinction and generalization. Pavlov J Biol Sci 9:25–34Google Scholar
  26. Smith MC, DiLollo V, Gormezano I (1966) Conditioned jaw movement in the rabbit. J Comp Physiol Psychol 62:479–483Google Scholar
  27. Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill, New YorkGoogle Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • I. Gormezano
    • 1
  • John A. Harvey
    • 1
  • Ellen Aycock
    • 1
  1. 1.Departments of Psychology and PharmacologyThe University of IowaIowa CityUSA

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