Abstract
Butoctamide hydrogen succinate (BAHS), related to an organic compound naturally occurring in the central nervous system (CNS), has been shown to increase REM sleep in chronically prepared cats. In the present study, we confirmed that BAHS increases REM sleep in healthy humans. The subjects were six males whose mean age was 21 years and the experiment covered eight consecutive nights. Identical capsules containing either a placebo (linolenic acid) or 600 mg BAHS were administered 1 h prior to recording, which was started at 11 p.m. There was little change in total sleep time, sleep efficiency index, sleep latency, REM sleep latency, or the number of REM sleep periods during the drug- as compared to the baseline periods. There were, however, significant increases in REM sleep and decreases in sleep stages 1 and 2. The night's sleep was divided into three equal portions and analysis of the percentage of sleep stages in each showed that REM sleep markedly increased in the middle third while stages 3 and 4 increased in the last third. A carryover effect of BAHS was recognized during the with-drawal period. The maximum percentage of BAHS-induced REM sleep was 34%. REM density during the drug periods tended to decrease. These results suggest that BAHS may be an efficacious hypnotic in that it increase REM sleep which is suppressed by other clinically used hypnotics.
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References
Ichikawa A, Kaneko H, Mori Y, Tomita K (1977) Release of serotonin from mast cells induced by N-(2-ethylhexyl)-3-hydroxybutyramide and catecholamine. Biochem Pharmacol 26:197–202
Ishida Y, Ohmoto M (1975) Potentiating actions of N-(2-ethylhexyl)-β-oxybutyramide (Hexobutyramide) on the 5-HT-contractions of isolated smooth muscle preparations. (In Japanese) Oyo Yakuri 9:573–578
Jouvet M, Cier A, Mounier D, Valtax JL (1961) Effects du 4-butyrolactone et du 4-hydroxybutyrate de sodium sur l'EEG et le comportement du chat. C R Soc Biol (Paris) 6:1313–1316
Kales A, Preston TA, Tan TL, Allen C (1970) Hypnotics and altered sleep-dream patterns, all-night EEG studies of glutethimide, methyprylon, and pentobarbital. Arch Gen Psychiatry 23:211–218
Kay DC, Blackburn AB, Buckingham JA (1976) Human pharmacology of sleep. In: Williams RL, Karacan I (eds) Pharmacology of sleep. Wiley, New York, p 83
Kleitman N (1963) Sleep and wakefulness. University of Chicago Press, Chicago
Matsuzaki M, Takagi H, Tokizane T (1964) Paradoxical phase of sleep: Its artificial induction in the cat by sodium butyrate. Science 146:1328–1329
Ohtomo E, Araki G, Tomita T, Koga E (1975) Effectiveness of N-(2-ethylhexyl)-β-oxybutyramide semisuccinate (M-2H) on sleep in insomniacs. (In Japanese). Igaku No Ayumi 92:258–273
Okuma T, Hata N, Fujii S (1975) Differential effects of chlorpromazine, imipramine, nitrazepam and amobarbital on REM sleep and REM density in man. Folia Psychiatr Neurol Jpn 29:25–37
Rechtschaffen A, Kales A (1968) A manual of standarized terminology, techniques and scoring system for sleep stages of human subjects. Public Health Service, U.S. Government Printing Office, Washington, DC
Torri S, Mitsumori K, Inubushi S, Yanagisawa I (1973) The REM sleep-inducing action of a naturally occurring organic bromine compound in the encephalé isolé cat. Psychopharmacologia 29:65–75
Torii S, Inubushi S, Sakuma A (1975) Effects of related compounds of naturally occurring bromosubstance on the sleep-wakefulness cycle in the cat. In: Weitzman ED (ed) Advances in sleep research, vol 2. Spectrum, New York, p 155
Webb WB, Agnew HW, Jr (1967) Sleep cycling within twenty-four hour periods. J Exp Psychol 73:158–160
Wyatt RJ, Zarcone V, Engelman K (1971) Effects of 5-hydroxytryptophan on the sleep of normal human subjects. Electroencephalogr Clin Neurophysiol 30:505–509
Yanagisawa I, Yoshikawa H (1973) A bromine compound isolated from human cerebrospinal fluid, and synthesis related compounds. Biochim Biophys Acta 329:283–294
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Okudaira, N., Torii, S. & Endo, S. The effect of butoctamide hydrogen succinate on nocturnal sleep: All-night polygraphical studies. Psychopharmacology 70, 117–121 (1980). https://doi.org/10.1007/BF00435301
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DOI: https://doi.org/10.1007/BF00435301