Summary
Mitotic segregation of three 2 μm-pBR322 chimaeric plasmids (YEp6, YEp21, and YEp24) was studied in yeast. Each displayed a characteristic rate of loss: YEp6 was lost at approximately twice the rate of YEp21 and YEp24. The loss rates were not significantly increased when two chimaeric plasmids were coresident, nor was the endogenous 2 μm plasmid itself displaced. Therefore these plasmids appear to be compatible in yeast.
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Warren, G.J. Mitotic segregation of 2 μm-pbr322 chimaeric plasmids in yeast. Curr Genet 7, 235–237 (1983). https://doi.org/10.1007/BF00434895
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DOI: https://doi.org/10.1007/BF00434895