Cancer Chemotherapy and Pharmacology

, Volume 5, Issue 4, pp 211–215 | Cite as

The use of four-drug combination chemotherapy (D.A.V.E.) in the treatment of advanced Wilms' tumour

  • D. B. Dunger
  • J. S. Malpas
  • J. R. Graham-Pole
  • M. R. Sandland
  • A. G. Stansfeld
  • J. E. Freeman
Original Articles Wilms' Tumour Chemotherapy


A study was begun in 1971 at St. Bartholomew's Hospital with a combination of 4 drugs, dactinomycin (actinomycin D), adriamycin, vincristine and Endoxan (cyclophosphamide) (D.A.V.E.), together with surgery and radiation, in the treatment of stage III and stage IV Wilms' tumour. Seventy-one percent of the children treated achieved complete response. The median survival from diagnosis was 19 months, and in those children achieving complete response the median disease-free survival has not yet been reached. Toxicity was not a serious problem.

The study group is compared with a group of children treated at this hospital before 1971. There is an improved survival in the children treated with D.A.V.E. Children who have relapsed with stage I or stage II disease may also respond.

This four-drug combination was well tolerated and effective, and confirms recent experience suggesting that intensive multiple-drug regimens may be curative even in advanced disease.


Cancer Research Cyclophosphamide Median Survival Advanced Disease Vincristine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • D. B. Dunger
    • 1
  • J. S. Malpas
  • J. R. Graham-Pole
    • 2
  • M. R. Sandland
  • A. G. Stansfeld
  • J. E. Freeman
    • 3
  1. 1.The Hospital for Sick ChildrenLondonGreat Britain
  2. 2.Department of Hematology/OncologyRainbow Babies and Children's HospitalCleveland
  3. 3.Cancer Therapy and Research CentreCancer Therapy and Research Foundation of South TexasSan AntonioUSA

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