Skip to main content
SpringerLink
Log in

ALG/alg: a single gene controlling the utilization of lactate in the presence of antimycin in the yeast Saccharomyces cerevisiae

  • Original Articles
  • Published:
Current Genetics Aims and scope Submit manuscript

Summary

A strain dependent growth on lactate in the presence of antimycin A (AA) has been observed — the strain D261 can grow on lactate and AA, whereas in the strain K8/6C antimycin A prevents the utilization of lactate and the induction of LDH.

Genetic analysis demonstrates that growth on lactate in the presence of AA segregates from D261 as a single nuclear factor which we indicate by ALG1 and alg1 in its dominant and recessive states. alg1 complements the gene(s) which give(s) rise to the same phenotype in K8/6C.

The analysis of the regulation by lactate of LDH in the absence and presence of AA and in rho − cells shows that growth on lactate and antimycin A is not corretated with the induction by lactate of LDH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Clark-Walker GD, Linnane AW (1967) J Cell Biol 34:1–14

    Google Scholar 

  • Ferrero I, Saccani MG, Rossi C, Viola AM, Puglisi PP (1981) Microbiologica 4:131–139

    Google Scholar 

  • Genga AM, Tassi F, Lodi T, Ferrero I (1983) Microbiologica 1:1–8

    Google Scholar 

  • Kanjuga Z, Bryla J, Slater EC (1969) Inhibitors around the antimycin-sensitive site in the respiratory chain. In: Bücher Th, Sies H (eds) Inhibitors — Tools in cell research. Springer, Berlin, pp 282–300

    Google Scholar 

  • Labeyrie F, Slonimski PP, Naslin L (1959) Biochim Biophys Acta 34:262–265

    Google Scholar 

  • Mortimer RK, Hawthorne DC (1969) Yeast genetics, chapt. 8. In: Rose AH, Harrison JS (eds) The yeasts, vol 1. Academic Press, New York

    Google Scholar 

  • Nygaard AP (1960) Biochim Biophys Acta 40:85–92

    Google Scholar 

  • Pajot P, Claisse ML (1974) Eur J Biochem 49:275–285

    Google Scholar 

  • Sherman F, Lawrence CW (1974) Saccharomyces, chapt. 24. In: King RC (ed) Handbook of genetics, vol 1. Plenum Press, New York

    Google Scholar 

  • Slonimski PP (1953) La formation des enzymes respiratoires chez la levure. Masson et Cie, Paris

    Google Scholar 

  • Slonimski PP, Perrodin G, Croft J (1968) Biochem Biophys Res Commun 30:232–239

    Google Scholar 

  • Somlo M (1965) Biochim Biophys Acta 97:183–201

    Google Scholar 

  • Somlo M (1966) Bull Soc Chim Biol XLVIII:247–276

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Genetics, University of Parma, borgo Carissimi 10, I-43100, Parma, Italy

    I. Ferrero, R. Rambaldelli, A. M. Genga, C. Donnini & P. P. Puglisi

Authors
  1. I. Ferrero
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Rambaldelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. M. Genga
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Donnini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. P. Puglisi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ferrero, I., Rambaldelli, R., Genga, A.M. et al. ALG/alg: a single gene controlling the utilization of lactate in the presence of antimycin in the yeast Saccharomyces cerevisiae . Curr Genet 8, 407–411 (1984). https://doi.org/10.1007/BF00433906

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00433906

Key words

Search

Navigation