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Haloperidol-induced plasma prolactin release: Sensitivity, reliability, and comparison to haloperidol antagonism of dopamine agonist-induced stereotyped behavior in the rat

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Abstract

The effects of a known antipsychotic agent (haloperidol) were assessed using both a behavioral model and a prolactin (PRL) model for screening potential antipsychotic drugs in the rat. The PRL model was found to be highly reliable and more sensitive than the behavioral model.

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Authors and Affiliations

  1. Department of Anatomy and Embryology, The Hebrew University, Hadassah Medical School, Box 1172, IL-91010, Jerusalem, Israel

    J. J. Feigenbaum & J. Yanai

  2. Department of Pharmacology and Neurological Sciences, Rush Medical College, Chicago, IL, USA

    B. H. Moon & H. L. Klawans

  3. Department of Obstetrics and Gynecology, Neuropsychiatric Institute, University of Illinois Medical Center, Chicago, IL, USA

    R. Catterton

Authors
  1. J. J. Feigenbaum
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  2. B. H. Moon
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  3. R. Catterton
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  4. J. Yanai
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  5. H. L. Klawans
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Feigenbaum, J.J., Moon, B.H., Catterton, R. et al. Haloperidol-induced plasma prolactin release: Sensitivity, reliability, and comparison to haloperidol antagonism of dopamine agonist-induced stereotyped behavior in the rat. Psychopharmacology 78, 383–384 (1982). https://doi.org/10.1007/BF00433748

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  • DOI: https://doi.org/10.1007/BF00433748

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