Abstract
C57BL mice normally show a preference for alcohol solutions compared with water. The effect of chronic, ethanol treatment sufficient to produce behavioural tolerance on the voluntary ethanol consumption of C57BL mice was compared with the effect of acute ethanol and acute and chronic administration of acetaldehyde. Chronic treatment with ethanol caused a loss of preference which lasted more than 12 weeks after withdrawal from the treatment. The acute ethanol treatment and the acute and chronic acetaldehyde treatments only produced a transient loss of preference which returned to normal within 1 week of cessation of treatment. The effect of these drugs on liver alcohol dehydrogenase (LAdH) was also examined. Changes in LAdH activity did not correlate with alcohol preference. Possible reasons for the different effects of the drug treatments on alcohol preference are discussed.
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Amit Z, Brown ZW, Rockman GE, Smith B, Amir S (1980) Acetaldehyde: a positive reinforcer mediating ethanol consumption. Adv Exp Med 126:413–423
Bergmeyer H-U (1963) Acetaldehyde determination with alcohol dehydrogenase from yeast. In: Bergmeyer H-U (ed) Method of enzymatic analysis. Verlag Chemie, Academics Press, London, pp 290–292
Bonnichsen RK, Theorell H (1951) An enzymatic method for the microdetermination of ethanol. Scand J Clin Lab Invest 3:58–62
Brown ZW, Amit Z, Smith B, Rockman GE (1978) Differential effects of conditioned taste aversion learning with peripherally and centrally administered acetaldehyde. Neuropharmacology 17:931–935
Collier HOJ (1966) Tolerance, physical dependence and receptors. A theory of the genesis of tolerance and physical dependence through drug-induced changes in the number of receptors. Adv Drug Res 3:171–188
Cunningham CL (1979) Flavor and location aversions produced by ethanol. Behav Neural Biol 27:362–368
Eriksson CJP (1980) The aversive effect of acetaldehyde on alcohol drinking behaviour in the rat. Alcohol: Clin Exp Res 4:107–111
Eriksson K (1969) Factors affecting voluntary alcohol consumption in the albino rat. Ann Zool Fennici 6:227–265
Eriksson K, Pikkrainen PH (1968) Differences between the sexes in voluntary alcohol consumption and liver ADH-activity in inbred strains of mice. Metabolism 17:563–1158
Hillbom ME, Lindros KO, Pösö AR, Eriksson L (1980) Cerebrospinal fluid acetaldehyde levels during ethanol intoxication in humans and experimental animals. In: Eriksson K, Sinclair JD, Kiianmaa K (eds) Animal models in alcohol research. Academic, New York, pp 469–474
Kakihana R, Brown DR, McClearn GE, Tabershaw IR (1966) Brain sensitivity to alcohol in inbred mouse strains. Science 154:1574–1575
Kakihara R, Butte JC (1980) Biochemical correlates of inherited drinking in laboratory animals. In: Eriksson K, Sinclair JD, Kiianmaa K (eds) Animal models in alcohol research. Academic, New York, pp 21–34
Kakihana R, McClearn GE (1963) Development of alcohol preference in BALB/c mice. Nature 199:511–512
McClearn GE, Rodgers DA (1959) Differences in alcohol preference among inbred strains of mice. Q J Stud Ale 20:691–695
Mezey E, Potter JJ, Harmon MS, Tsitouras PD (1980) Effects of castration and testosterone administration on rat liver alcohol dehydrogenase activity. Biochem Pharmacol 29:3175–3180
Rachamin G, Macdonald JA, Wah DS, Clapp JJ, Khanna JM, Israel Y (1980) Modulation of alcohol dehydrogenase and ethanol metabolism by sex hormones in the spontaneously hypertensive rat. Effect of chronic ethanol administration. Biochem J 186:483–490
Sinclair JD (1980) Comparison of the factors which influence voluntary drinking in humans and animals. In: Eriksson K, Sinclair JD, Kiianmaa K (eds) Animal models in alcohol research. Academic, New York, pp 119–138
Taberner PV, Unwin JW (1981) Ethanol preference after chronic ethanol drinking in mice. Br J Pharmacol 74:959P
Unwin, JW, Taberner PV (1980) Sex and strain differences in GABA receptor binding after chronic ethanol drinking in mice. Neuropharmacology 19:1257–1259
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Unwin, J.W., Taberner, P.V. Voluntary ethanol consumption after ethanol and acetaldehyde treatment in alcohol-preferring C57BL mice. Psychopharmacology 78, 361–364 (1982). https://doi.org/10.1007/BF00433742
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DOI: https://doi.org/10.1007/BF00433742