Abstract
The effect of long-term treatment with fencamfamine on swimming endurance and availability of metabolic substrates was investigated in mice. Fencamfamine (14 μg/g per day orally for 6 weeks) reduced maximum swimming capacity by more than 40%. This effect could not be attributed to motor incoordination or a diminution of pre-swimming levels of metabolic substrates such as liver and muscle glycogen or blood glucose and non-esterified fatty acids. However, during swimming the hepatic and muscular glycogen stores were depleted more rapidly in the fencamfamine-treated animals. Thus it appears that fencamfamine leads more rapidly to a shortage of combustible substrates in the swimming animals.
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Duncombe, W. G.: The colorimetric micro-determination of nonesterified fatty acids in plasma. Clin. Chim. Acta 9, 122–125 (1964)
Estler, C.-J., Ammon, H. P. T., Herzog, C.: Swimming capacity of mice after prolonged treatment with psychostimulants. I. Effect of caffeine on swimming performance and cold stress. Psychopharmacology 58, 161–166 (1978)
Estler, C.-J., Gabrys, M. C.: Swimming capacity of mice after prolonged treatment with psychostimulants. II. Effect of methamphetamine on swimming performance and availability of metabolic substrates. Psychopharmacology 60, 173–176 (1979)
Hotovy, R., Enenkel, H. J., Gillissen, J., Hoffmann, A., Jahn, U., Kraft, H. G., Müller-Calgan, H., Sommer, S., Struller, R.: Pharmakologische Eigenschaften des 2-Äthylamino-3-phenylnorcamphan. Arzneim. Forsch 11, 20–24 (1961)
Keppler, D., Decker, K.: Glycogen. Bestimmung mit Aminoglucosidase. In: Methoden der enzymatischen Analyse, H. U. Bergmeyer ed., pp. 1171–1176. Weinheim: Verlag Chemie 1974
Neumann, K.-H.: Tierversuche zur Frage körperlichen Leistungsvermögens nach Aufnahme von Koffein. Med. Klin. 60, 1354–1356 (1965)
Sommer, S., Hotovy, R.: Zur Differenzierung der zentralerregenden Wirkung von 2-Äthylamino-3-phenyl-norcamphan. Arzneim. Forsch. 11, 969–972 (1961)
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Estler, C.J., Gabrys, M.K. Swimming capacity of mice after prolonged treatment with psychostimulants. Psychopharmacology 63, 281–284 (1979). https://doi.org/10.1007/BF00433562
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DOI: https://doi.org/10.1007/BF00433562