Virchows Archiv A

, Volume 385, Issue 1, pp 117–124 | Cite as

Liposarcoma of the breast

Case report and review of the literature
  • Jan Rasmussen
  • Helle Jensen
Case Report


A case of primary liposarcoma of the breast in a 65-years-old woman is described by light- and electron microscopy. The patient had previously had a cystosarcoma phyllodes removed from the same area.

A review of the literature showed 34 previously published cases of liposarcoma of the breast, which regarding age distribution, histological type and pattern of metastasis corresponded to liposarcomas of the lower limbs.

Key words

Liposarcoma Breast Histopathology Electron microscopy 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adair, F.E., Herrmann, J.B.: Sarcoma of the breast. Surgery 19, 55–73 (1946)Google Scholar
  2. Anderson, D.K., Kafrouni, G.I.: Mammary liposarcoma. Int. Surg. 57, 67–69 (1972)Google Scholar
  3. Binkert, M.: Fibrolipoadenoma intracanaliculare sarcomatodes xanthomatodes mammae. Frankf. Z. Pathol. 30, 498–511 (1924)Google Scholar
  4. Blichert-Toft, M., Hansen, J.P.H., Hansen, O.H., Schiødt, T.: Cystosarcoma phyllodes of the breast. Ugeskr. Læg. 139, 2501–2504 (1977)Google Scholar
  5. Botham, R.J., McDonald, J.R., Clagett, O.T.: Sarcoma of the mammary gland. Surg. Gynec. Obstet. 107, 55–61 (1958)Google Scholar
  6. Breckenridge, R.L.: Liposarcoma of the breast. Report of a case. Am. J. Clin. Pathol. 24, 954–956 (1954)Google Scholar
  7. Carpanelli, J.B., Lempel, G., Gatta, C.: Sobre un caso de liposarcoma de glandula mamaria. La Semana méd. 123, 321–322 (1963)Google Scholar
  8. Cuthbertson, A.N.: Liposarcoma of breast. Postgrad. Med. 20, 160 (1956)Google Scholar
  9. Delage, J., Massabiau: Les lipomes du sein et de la région mammaire. Rev. Chir. (Paris) 30, 484–506 (1904)Google Scholar
  10. De Navasquez, S., Horton, R.E.: Liposarcoma of the breast. Guy's Hosp. Rep. 96, 57–59 (1947)Google Scholar
  11. Enterline, H.T., Culberson, J.D., Rochlin, D.B., Brady, L.W.: Liposarcoma. A clinical and pathological study of 53 cases. Cancer 13, 932–950 (1960)Google Scholar
  12. Enzinger, F.M., Winslow, D.J.: Liposarcoma. A study of 103 cases. Virchows Arch. Path. Anat. 335, 367–388 (1962)Google Scholar
  13. Enzinger, F.M., Lattes, R., Torlino, H.: Histological typing of soft tissue tumours, p. 20. Geneva: WHO 1969Google Scholar
  14. Flenker, H.: Myxoid liposarcoma. Light and electron microscopic investigation. Virchows Arch. A Path. Anat. and Histol. 371, 171–176 (1976)Google Scholar
  15. Fox, S.L.: Sarcoma of the breast. With a report of sixty cases. Ann. Surg. 100, 401–421 (1934)Google Scholar
  16. Geschickter, C.F.: Diseases of the breast. 2nd ed., p. 386. Philadelphia: J.B. Lippincott Co. 1943Google Scholar
  17. Hinterberger, H.: Zur Kenntnis des Sarkoma phyllodes lipomatodes mammae. Wien. Klin. Wochenschr. 55, 28–32 (1942)Google Scholar
  18. Homes, R.S., Leis, H.P.: Liposarcoma of the female breast. Review of the literature and report of a case. J. Am. Geriatrics Soc. 10, 455–459 (1962)Google Scholar
  19. Hummer, C.D., Burkart, T.J.: Liposarcoma of the breast. A case of bilateral involvement. Am. J. Surg. 113, 558–561 (1967)Google Scholar
  20. Jackson, A.V.: Metastasising liposarcoma of the breast, arising in a fibro-adenoma. J. Pathol. Bacteriol. 83, 582–584 (1962)Google Scholar
  21. Johannessen, J.V.: Diagnostic electron microscopy. Part 2, pp. 38–39 and pp. 70–71. London: Philips and LKB 1977Google Scholar
  22. Kalderon, A.E., Fethiere, W.: Fine structure of two liposarcomas. Lab. Invest. 28, 60–69 (1973)Google Scholar
  23. Karnovsky, M.J.: A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. J. Cell Biol. 27, 137a-138a (1965)Google Scholar
  24. Kindblom, L.G., Angervall, L., Svendsen, P.: Liposarcoma. A clinicopathologic, radiographic and prognostic study. Acta Pathol. Microbiol. Scand. Sect. A Suppl. 253, 1–71 (1975)Google Scholar
  25. Kindblom, L.G., Säve-Söderbergh, J.: The ultrastructure of liposarcoma. A study of 10 cases. Acta Pathol. Microbiol. Scand. Sect. A 87, 109–121 (1979)Google Scholar
  26. Kristensen, P.B., Kryger, H.: Liposarcoma of the breast. A case report. Acta Chir. Scand. 144, 193–196 (1978)Google Scholar
  27. Lifvendahl, R.A.: Liposarcoma of the mammary gland. Surg. Gynecol. Obstet. 50, 81–84 (1930)Google Scholar
  28. MacFarlane, A.: Liposarcoma of the breast. Br. J. Surg. 45, 106–107 (1957)Google Scholar
  29. McGregor, J.K.: Liposarcoma of the breast. Case report and review of the literature. Canad. Med. Ass. J. 82, 781–783 (1960)Google Scholar
  30. Menon, M., van Velthoven, P.CM.: Liposarcoma of the breast. A case report. Arch. Pathol. 98, 370–372 (1974)Google Scholar
  31. Merkel, H.: Über ein Pseudolipom der Mamma. Beitr. Path. Anat. 39, 152–157 (1906)Google Scholar
  32. Michalany, J.: Liposarcoma da glandula mamaria. Hospital (Rio de Janeiro) 39, 655–661 (1951)Google Scholar
  33. Neal, M.P.: Malignant tumors of the male breast. Arch. Surg. 27, 451–465 (1933)Google Scholar
  34. Neumann, E.: Beiträge zur Casuistik der Brustdrüsengeschwülste. Virchows Arch. Path. Anat. 24, 316–328 (1862)Google Scholar
  35. Qizilbash, A.H.: Cystosarcoma phyllodes with liposarcomatous stroma. Am. J. Clin. Pathol. 65, 321–327 (1976)Google Scholar
  36. Reynolds, E.S.: The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17, 208–212 (1963)Google Scholar
  37. Scarpelli, D.G., Greider, M.H.: A correlative cytochemical and electron microscopic study of a liposarcoma. Cancer 15, 776–789 (1962)Google Scholar
  38. Stout, A.P., Benanke, M.: Liposarcoma of the female mammary gland. Surg. Gynecol. Obstet. 83, 216–218 (1946)Google Scholar
  39. Tedeschi, C.G.: Mammary lipoma. Arch. Pathol. 46, 386–397 (1948)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Jan Rasmussen
    • 1
  • Helle Jensen
    • 1
  1. 1.Department of PathologyThe Finsen InstituteCopenhagenDenmark

Personalised recommendations