Skip to main content
SpringerLink
Log in

The ontogeny of aggregation-enhanced toxicity

  • Short Reports
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Sensitivity to the lethal effects of methamphetamine was observed under grouped conditions relative to isolated conditions in rats 25 and 30 days old but not in rats 7, 10, 15, or 20 days of age. Results are interpreted in terms of the development of the central catecholaminergic systems through which methamphetamine is thought to induce toxicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Alhava E, Klinge E (1972) Age and brain catecholamine content as factors influencing amphetamine toxicity in mice. Acta Pharmacol Toxicol 31:401–411

    Google Scholar 

  • Campbell BA, Randall PJ (1977) Paradoxical effects of amphetamine on preweanling and post weanling rats. Science 195:888–891

    Google Scholar 

  • Gunn JA, Gurd MR (1940) The action of some amines related to adrenaline. Cyclohexylalkylamines. J Physiol (London) 97:453–470

    Google Scholar 

  • Harri MN (1976) Amphetamine toxicity in temperature acclimatised mice. Acta Pharmacol Toxicol 38:1–9

    Google Scholar 

  • Lal S, Sourkes TL (1973) Ontogeny of stereotyped behavior induced by apomorphine and amphetamine in the rat. Arch Int Pharmacodyn Ther 202:171–182

    Google Scholar 

  • Lanier LP, Dunn AJ, van Hartesveldt C (1978) Development of neurotransmitters and their function in brain. In: Ehrenpreis S, Kopin IJ (eds) Review of neuroscience, II. Raven Press, New York, pp 195–256

    Google Scholar 

  • Litchfield JT, Wilcoxon F (1949) A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96:99–113

    Google Scholar 

  • Lokiec FC, Jacquot CR, Rapin JR, Cohen Y (1977) Effects of amphetamine on brain biogenic amines in isolated and aggregated rats. Eur J Pharmacol 44:391–395

    Google Scholar 

  • Moore KE (1964) The role of endogenous norepinephrine in the toxicity of d-amphetamine in aggregated mice. J Pharmacol Exp Ther 144:45–51

    Google Scholar 

  • Reid WD (1970) Turnover rate of brain 5-hydroxytryptamine increased by d-amphetamine. Br J Pharmacol 40:483–492

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Biopsychology, University of Chicago, 60637, Illinois, USA

    George C. Wagner

  2. Dept. of Pharmacology, Wright State University Dayton, Ohio, USA

    James B. Lucot

  3. Dept. of Psychiatry, University of Chicago, Chicago, Illinois, USA

    Charles R. Schuster & Lewis S. Seiden

  4. Dept. of Pharmacological and Physiological Sciences, University of Chicago, Chicago, Illinois, USA

    Charles R. Schuster & Lewis S. Seiden

Authors
  1. George C. Wagner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. James B. Lucot
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Charles R. Schuster
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lewis S. Seiden
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by Searle Fellowship

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wagner, G.C., Lucot, J.B., Schuster, C.R. et al. The ontogeny of aggregation-enhanced toxicity. Psychopharmacology 75, 92–93 (1981). https://doi.org/10.1007/BF00433509

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00433509

Key words

Search

Navigation