Psychopharmacology

, Volume 75, Issue 1, pp 25–30 | Cite as

Psychostimulant self-administration by beagle dogs in a progressive-ratio paradigm

  • Marc E. Risner
  • Dennis L. Silcox
Original Investigations

Abstract

The relative reinforcing efficacy of cocaine, amphetamine, mazindol, and fenfluramine was quantified using a progressive-ratio paradigm. Catheterized beagle dogs (N=6) were given access to response-contingent drug infusions during three 1-h trials each day. According to a predetermined schedule, the response requirement to obtain one infusion each trial was increased daily until the dogs failed to complete the necessary fixed-ratio (FR); i. e., until they reached a “break-point” in their ratio behavior. Fenfluramine (in doses ranging from 0.0625–4.0 mg/kg/infusion) did not maintain self-administration behavior at or above the minimum requirement (FR 30). In contrast, all doses of cocaine (0.2–1.6 mg/kg/infusion), d-amphetamine (0.035–0.28 mg/kg/infusion), and mazindol (0.0225–0.18 mg/kg/infusion) sustained responding at large FR values. The highest FR values were maintained by cocaine, followed by d-amphetamine, then mazindol. Generally the dogs completed higher FRs for higher doses of a drug.

Key words

Self-administration Reinforcing efficacy Progressive-ratio Dog Cocaine Amphetamine Mazindol Fenfluramine 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Marc E. Risner
    • 1
  • Dennis L. Silcox
    • 1
  1. 1.National Institute on Drug Abuse, Division of ResearchAddiction Research CenterLexingtonUSA

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