Abstract
Chlordiazepoxide (CDP) and amphetamine (AMPH) were tested, alone or in combination, in BALB/c mice pretreated with α-methyl-p-tyrosine (AMT) and subjected to shuttle-box avoidance training.
CDP and AMPH, given alone, partly reversed avoidance depression induced by 50 mg/kg of AMT, but were ineffective in mice pretreated with 100 mg/kg of AMT. Stronger effects were produced by CDP-AMPH combinations, which also improved avoidance performance in mice pretreated with the higher dose of AMT.
The results suggest that catecholamines may play a role in the facilitation of avoidance induced by CDP, especially when given in combination with AMPH.
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Sansone, M., Renzi, P. Avoidance facilitation by chlordiazepoxide-amphetamine combinations in mice: Effect of α-methyl-p-tyrosine. Psychopharmacology 75, 22–24 (1981). https://doi.org/10.1007/BF00433495
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DOI: https://doi.org/10.1007/BF00433495