Abstract
The effect of methylglucamine orotate (MGO) on learning and memory was investigated in 24-month-old rats using brightness discrimination in a Y-chamber and active avoidance in a shuttle box. In both learning procedures, an improvement of memory retention following 5-day MGO treatment (225 mg/kg per day) was observed. The retention of untreated old animals was significantly lower compared to 8-week-old rats. MGO treatment resulted in a significant improvement of retention in old rats, which nearly compensated for their memory deficit.
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Rüthrich, HL., Wetzel, W. & Matthies, H. Memory retention in old rats: Improvement by orotic acid. Psychopharmacology 79, 348–351 (1983). https://doi.org/10.1007/BF00433416
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DOI: https://doi.org/10.1007/BF00433416