Abstract
Observations that the long-sleep (LS) and short-sleep (SS) mouse lines differ in their depressant response to barbiturates, and that the difference between lines becomes greater as lipid solubility increases, prompted this investigation of the effects of alcohols that differ in lipid solubility. Results indicate that LS and SS mice differ significantly in their sleep time responses to propanol, butanol, and 3-methyl butanol, as well as ethanol: their hypothermic responses showed a similar pattern, but only the response to ethanol differed significantly between lines. For both sleep time and hypothermia, the difference between lines decreased with increasing lipid solubility. In all cases, the LS mice were more sensitive than the SS to the depressant effects of the alcohol. Similar ratios of SS:LS waking brain ethanol and butanol levels indicated that CNS sensitivity to long-chain alcohols is similar to that for ethanol. A pharmacokinetic study revealed higher ethanol levels for LS than for SS mice at all time points in blood, fat, and brain body compartments. Blood ethanol elimination curves showed that the SS mice eliminate ethanol at a faster rate than do the LS.
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References
Baker RC, Melchior C, Deitrich R (1980) The effect of halothane on mice selectively bred for differential sensitivity to ethanol. Pharmacol Biochem Behav 12:691–698
Bigelow SW, Collins AC, Nebert DW (1983) Association of ethanol response with the Ah locus. J Biol Chem (in press)
Collins AC, Yeager TN, Lebsack MD, Panter SS (1975) Variations in alcohol metabolism: Influence of sex and age. Pharmacol Biochem Behav 3:973–978
Erwin VG, Heston WDW, McClearn GE, Deitrich RA (1976) Effect of hypnotics on mice genetically selected for sensitivity to ethanol. Pharmacol Biochem Behav 4:679–683
French TA, Atkinson N, Petersen DR, Chung LWK (1979) Differential induction of hepatic microsomal ethanol and drug metabolism by 3-methylcholanthrene in ‘LS’ and ‘SS’ mice. J Pharmacol Exp Ther 209:404–410
Gilliam DM, Bloedow DC, Collins AC (1983) Nonlinear pharmacokinetics of ethanol in LS and SS mice. Alcoholism (in press)
Gilliam DM, Collins AC (1982) Circadian and genetic effects on ethanol elimination in LS and SS mice. Alcoholism 6:344–349
Gilliam DM, Collins AC (1983) Circadian and genetic influences on tissue sensitivity and sleep time to ethanol. Pharmacol Biochem Behav (in press)
Heston WDW, Erwin VG, Anderson SM, Robbins HA (1974) A comparison of the effects of alcohol on mice selectively bred for differences in ethanol sleep time. Life Sci 14:365–370
Hjelle JJ, Atkinson N, Petersen DR (1981) The effects of chronic ethanol ingestion on ethanol binding to hepatic cytochrome P-450 and on certain hepatic and renal parameters in the ‘long-sleep’ and ‘short-sleep’ mouse. Alcoholism 5:198–203
Koblin DD, Deady JE (1981) Anaesthetic requirement in mice selectively bred for differences in ethanol sensitivity. Br J Anaesthesiol 53:5–10
McClearn GE, Kakihana R (1981) Selective breeding for ethanol sensitivity: SS and LS mice. In: McClearn GE, Deitrich RA, Erwin VG (eds) Development of animal models as pharmacogenetic tools (DHHS Publication ADM 81-1133). US Government Printing Office, Washington DC, pp 147–159
McClearn GE, Wilson JR, Meredith W (1970) The use of isogenic and heterogenic mouse stocks in behavioral research. In: Lindzey G, Thiessen DD (eds) Contributions to behavior-genetic analysis: The mouse as a prototype. Appleton Century Crofts, New York, pp 3–22
O'Connor MF, Howerton TC, Collins AC (1982) Effects of pentobarbital in mice selected for differential sensitivity to ethanol. Pharmacol Biochem Behav 17:245–248
Redetzki HM, Dees WL (1976) Comparison of four kits for enzymatic determination of ethanol in blood. Clin Chem 22:83–86
Siemens B, Chan AWK (1976) Differential effects of pentobarbital and ethanol in mice. Life Sci 19:581–590
Tabakoff B, Ritzmann RF, Raju TS, Deitrich RA (1980) Characterization of acute and chronic tolerance in mice selected for inherent differences in sensitivity to ethanol. Alcoholism 4:70–73
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Howerton, T.C., O'Connor, M.F. & Collins, A.C. Differential effects of long-chain alcohols in long- and short-sleep mice. Psychopharmacology 79, 313–317 (1983). https://doi.org/10.1007/BF00433408
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DOI: https://doi.org/10.1007/BF00433408