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Regulation of S-amino acids biosynthesis in Saccharomycopsis lipolytica

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Summary

ATP-sulfurylase, cysteine synthase, homocysteine synthase, arylsulfatase and β-cystathionase in Saccharomycopsis lipolytica are repressed on the addition of methionine, homocysteine or cysteine to the growth medium. The use of appropriate mutants enabled us to demonstrate that the synthesis of these enzymes is regulated by the system involving at least two low-molecular weight effectors — most likely cysteine and methionine (or their close derivatives).

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Abbreviations

SAM:

S-adenosylmethionine

OAS:

O-acetyl-L-serine

OAH:

O-acetyl-L-homoserine

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Authors and Affiliations

  1. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Rakowiecka 36, 02-532, Warsaw, Poland

    Ewa Morzycka & Andrzej Paszewski

Authors
  1. Ewa Morzycka
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  2. Andrzej Paszewski
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Communicated by F. Kaudewitz

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Morzycka, E., Paszewski, A. Regulation of S-amino acids biosynthesis in Saccharomycopsis lipolytica . Molec. Gen. Genet. 174, 33–38 (1979). https://doi.org/10.1007/BF00433302

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  • DOI: https://doi.org/10.1007/BF00433302

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