, Volume 71, Issue 1, pp 71–74 | Cite as

Effects of marihuana on pregnant rats and their offspring

  • Ernest L. Abel
  • Barbara A. Dintcheff
  • Nancy Day
Original Investigations


Pregnant rats were intubated with marihuana extract (10, 150 mg/kg) from gestation day 3 to parturition. Control animals were pair-fed. At parturition pups were culled and assigned to nondrug-treated dams. A positive control group consisting of animals prenatally exposed to alcohol (6 g/kg/day) was included for comparison of birth weight data. Marihuana reduced food and water consumption and maternal weight gain. Pup weight at birth was reduced by about 10% relative to pair-fed controls in animals exposed to the high doses of marihuana, and by approximately 15% in pups exposed to alcohol relative to their pairfed controls. Litter size and pup mortality at birth were not affected significantly. Postnatal mortality was increased and neonatal weight was decreased at 21 days in marihuana-treated offspring. At 11 weeks of age body weights of drug-treated females but not males, were still significantly less than that of pair-fed controls.

Key words

Marihuana Pregnancy Body weight Mortality Alcohol 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Ernest L. Abel
    • 1
  • Barbara A. Dintcheff
    • 1
  • Nancy Day
    • 1
  1. 1.Research Institute on AlcoholismBuffaloUSA

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