Abstract
A morphometric analysis of the effect of LSD on synapses was performed in the habenulae and the interpeduncular nucleus of the frog. The OsO4-fixed nervous tissue was treated with ethanol phosphotung-stic acid (EPTA). Intersection of lattice lines with synapses were counted as a proportion of the total length of lines. LSD-treated frogs had a higher total area of synaptic contact than control frogs. Exocytosis profiles were observed only in LSD-treated frogs. Other qualitative changes in the ultrastructural characteristic of synapses were appreciable after LSD administration.
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This work was in part supported by Grant of theItalian National Research Council CT 780214004.
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Kemali, M., Kemali, D. Lysergic acid diethylamide: Morphological study of its effect on synapses. Psychopharmacology 69, 315–317 (1980). https://doi.org/10.1007/BF00433103
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DOI: https://doi.org/10.1007/BF00433103