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Psychopharmacology

, Volume 69, Issue 3, pp 295–298 | Cite as

Motor depression and head twitches induced by IP injection of GABA

  • Antoni Śmiałowski
  • Maria Śmiałowska
  • Krystyna Reichenberg
  • Bożena Byrska
  • Jerzy Vetulani
Original Investigations

Abstract

Influence of GABA on locomotor activity and gross behavior of mice, rats, and rabbits was studied. In mice and rats, IP GABA injection produced decreased locomotor activity, but in rats and rabbits head twitches and disturbances in body balance were seen. GABA-induced head twitches were inhibited by picrotoxin, clonidine, morphine, or cyproheptadine. Our results suggest a serotonergic component in GABA-induced head twitches, but it is not the only mechanism involved in this behavior.

Key words

GABA Locomotor activity Head twitches Serotonin 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Antoni Śmiałowski
    • 1
  • Maria Śmiałowska
    • 1
  • Krystyna Reichenberg
    • 1
  • Bożena Byrska
    • 1
  • Jerzy Vetulani
    • 1
  1. 1.Institute of PharmacologyPolish Academy of SciencesKrakówPoland

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