Abstract
d-Amphetamine (0.5 and 1.0 mg/kg) and dl-fenfluramine (2.0 and 4.0 mg/kg) reduced food intake in a short exposure feeding test, and their effects were counteracted by chlordiazepoxide, particularly at 5.0 mg/kg. Chlordiazepoxide reduced latency to eat, extended the duration of feeding and depressed the rate of feeding. Antagonism occurred in combination with d-amphetamine in relation to latency and duration, but in this experiment d-amphetamine did not affect feeding rate. Antagonism also occurred in combination with fenfluramine, with latency and duration measures, but only at the lower chlordiazepoxide dose. Instead, chlordiazepoxide (10.0 mg/kg) enhanced fenfluramine's effects to reduce feeding duration and feeding rate.
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Cooper, S.J., Francis, R.L. Interactions of chlordiazepoxide and anorectic agents on rate and duration parameters of feeding in the rat. Psychopharmacology 69, 261–265 (1980). https://doi.org/10.1007/BF00433092
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DOI: https://doi.org/10.1007/BF00433092