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Hyperplastic and metaplastic lesions in the reproductive tract of male rats induced by neonatal treatment with diethylstilbestrol

Virchows Archiv A volume 376, pages 21–28 (1977)Cite this article

Summary

Newborn male Wistar rats were castrated on the day of birth (=day 1) and treated daily with diethylstilbestrol (DES) from days 1 to 30; 1 Μg for the first 10 days of life, 2 Μg for the next 10 days and 4 Μg for the last 10 days. The animals were autopsied at 30, 90 and 270 days of age. The epithelium of the coagulating glands (CGs) and ejaculatory ducts (EDs) underwent metaplastic transformation in all DES-treated rats. These pathological changes were more marked with age. The most striking changes were found in the periurethral regions of the CGs and EDs and associated regions of the dorsal urethral wall. The normal transitional epithelial lining almost disappeared and large papillary epithelial outgrowths occurred near the opening of the EDs and CGs. This type of neoplastic change was most marked in the group of rats sacrificed at 9 months of age.

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Affiliations

  1. Department of Anatomy, Juntendo University School of Medicine, Hongo, 113, Tokyo, Japan

    Yasumasa Arai & Yoshihide Suzuki

  2. Laboratory of Experimental Pathology, Aichi Cancer Research Institute, Chikusa-ku, 464, Nagoya, Japan

    Yasuaki Nishizuka

Authors
  1. Yasumasa Arai
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  2. Yoshihide Suzuki
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  3. Yasuaki Nishizuka
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Arai, Y., Suzuki, Y. & Nishizuka, Y. Hyperplastic and metaplastic lesions in the reproductive tract of male rats induced by neonatal treatment with diethylstilbestrol. Virchows Arch. A Path. Anat. and Histol. 376, 21–28 (1977). https://doi.org/10.1007/BF00433082

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  • DOI: https://doi.org/10.1007/BF00433082

Key words

  • Epithelial lesions
  • Male reproductive tract
  • Neonatal diethylstilbestrol treatment