Abstract
Four benzodiazepine tranquilizers have been tested, alone or in combination with scopolamine, on the spontaneous locomotor activity of BALB/c mice. Scopolamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. These effects are similar to those exerted by the four benzodiazepines on amphetamine-induced locomotor stimulation and allow the same differentiation between the four derivatives.
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References
Ahtee L, Shillito E (1970) The effect of benzodiazepines and atropine on exploratory behaviour and motor activity of mice. Br J Pharmacol 40:361–371
Oliverio A, Eleftheriou BE, Bailey DW (1973) Exploratory activity: Genetic analysis of its, modification by scopolamine and amphetamine. Physiol Behav 10:893–899
Sansone M (1980) Influence of benzodiazepine tranquilizers on amphetamine-induced locomotor stimulation in mice Psychopharmacology 71:63–65
Sansone M, Hano J (1979) Enhancement by chlordiazepoxide of the anticholinergic-induced locomotor stimulation in mice. Psychopharmacology 64:181–184
Soubrié P, Simon P, Boissier JR (1976) Antogonism of diazepam against central antocholinergic drug-induced hyperactivity in mice: involvement of GABA mechanism. Neuropharmacology 15:773–776
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Sansone, M. Influence of benzodiazepine tranquilizers on scopolamine-induced locomotor stimulation in mice. Psychopharmacology 71, 243–245 (1980). https://doi.org/10.1007/BF00433058
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DOI: https://doi.org/10.1007/BF00433058