Abstract
Atropine sulphate (10 mg/kg IP) afforded 90% protection against clonic convulsions induced by standard doses of metrazol (80 mg/kg SC) in mice, whereas atropine methonitrate (10 mg/kg IP) did not offer any protection. Furthermore, physostigmine (1 mg/kg IP) caused recurrence of convulsions in atropinzed metrazol-treated mice and converted the subconvulsive dose of metrazol (40 mg/kg SC) into a 100% convulsive dose. However, neostigmine (1 mg/kg IP) did not antagonize the protection afforded by atropine sulphate against metrazol. The results of the study suggest an involvement of central cholinergic mechanisms in metrazol-induced convulsions.
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Rastogi, S.K., Puri, J.N., Sinha, J.N. et al. Involvement of central cholinoceptors in metrazol-induced convulsions. Psychopharmacology 65, 215–217 (1979). https://doi.org/10.1007/BF00433052
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DOI: https://doi.org/10.1007/BF00433052