Abstract
This study in normal male subjects further investigates the effects of dopaminergic-antidopaminergic interactions as manifested by the prolactin response to dopamine and neuroleptic drugs. Incremental doses of dopamine hydrochloride (4 μg/min, 15 μg/min, 60 μg/min, 300 μg/min) were infused fused at a constant rate over 90–120 min after a fixed dose of a neuroleptic drug (sufficient for about half of the maximal prolactin response) had been given IV. A dose of dopamine in the order of 15–60 μg/min appeared to match the “los” of endogenous dopaminergic inhibition due to the antidopaminergic effect of the neuroleptic drug. The lactotrophic cells of the pituitary gland are suggested to serve as a model in man for the study of some basic neurohormonal mechanisms.
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Kleinberg, D. L., Noel, G. L., Frantz, A. G.: Chlorpromazine stimulation and l-dopa suppression of plasma prolactin in man. J. Clin. Endocrinol. Metab. 33, 873–879 (1971)
Langer, G., Sachar, E. J., Halpern, F. S., Gruen, P. H., Solomon, M.: The prolactin response to neuroleptic drugs. A test of dopaminergic blockade: Neuroendocrine studies in normal men. J. Clin. Endocrinol. Metab. 45, 996–1002 (1977a)
Langer, G., Sachar, E. J., Gruen, P. H., Halpern, F. S.: Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency. Nature. 226, 639–640 (1977b)
Langer, G., Ferin, M., Sachar, E. J.: Effect of haloperidol and l-dopa on plasma prolactin in stalk-sectioned and intact monkeys. Endocrinology 102, 367–370 (1978a)
Langer, G., Sachar, E. J., Halpern, F. S.: Effect of dopamine and neuroleptics on plasma growth hormone and prolactin in normal men. Psychoneuroendocrinology 3, 165–169 (1978b)
Lu, K. H., Meites, J.: Effects of l-dopa on serum prolactin and PIF in intact and hypophysectomized, pituitary-grafted rats. Endocrinology 91, 868–876 (1972)
Macleod, R. M.: Regulation of prolactin secretion. In: Frontiers in neuroendocrinology, L. Martini, W. F. Ganong, eds., pp. 169–195. New York: Raven 1976
Shostak, M., Perel, J. M.: A radioimmunoassay of haloperidol. Fed. Proc. 35, 531 (1976)
Sinha, Y. N., Selby, F. W., Lewis, U. J., Vanderlaan, W. P.: A homologous radioimmunoassay for human prolactin. J. Clin. Endocrinol. Metab. 36, 509–515 (1973)
Snyder, S. H., Banerjee, S. P., Yamamura, H. I., Greenberg, D.: Drugs, neurotransmitters, and schizophrenia. Science 184, 1243–1253 (1974)
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Langer, G., Sachar, E.J., Nathan, R.S. et al. Dopaminergic factors in human prolactin regulation: A pituitary model for the study of a neuroendocrine system in man. Psychopharmacology 65, 161–164 (1979). https://doi.org/10.1007/BF00433043
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DOI: https://doi.org/10.1007/BF00433043