, Volume 65, Issue 2, pp 137–140 | Cite as

Prolongation of the ejaculation latency in the male rat by thioridazine and chlorimipramine

  • Sven Ahlenius
  • Mikael Heimann
  • Knut Larsson
Original Investigations


Thioridazine (3 mg/kg) and chlorimipramine (1.5–6.0 mg/kg) prolonged the ejaculation latency and increased the number of mounts but did not change the number of intromissions preceding ejaculation. Blockade of peripheral and central noradrenaline receptors by phentolamine and phenoxybenzamine respectively resulted in a suppression of all aspects of the sexual behavior with increasing doses. dl-5-HTP (25–100 mg/kg) in combination with an inhibitor of peripheral 5-HTP decarboxylase (benserazide, 25 mg/kg) produced, like chlorimipramine and thioridazine, a prolongation of ejaculation latency and an increase in the number of mounts preceding ejaculation. Selective inhibition of 5-HT reuptake however, by zimelidine (0–20 mg/kg) or alaproclate (0–20 mg/kg) did not affect the mating behavior. At higher doses of these drugs some animals failed to initiate sexual activities. There was an increase in the postejaculatory interval but no change in the ejaculatory latency.

It is concluded that the prolonged ejaculation latencies observed following treatment with thioridazine or chlorimipramine is not due to a blockade of central or peripheral adrenergic α-receptors.

Key words

Male sexual behavior Rat Monoamines Thioridazine Chlorimipramine 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ahlenius, S., Eriksson, H., Larsson, K., Modigh, K., Södersten, P.: Mating behavior in the male rat treated with p-chlorophenylalanine methyl ester alone and in combination with pargyline. Psychopharmacologia 20, 383–388 (1971)Google Scholar
  2. Andén, N.-E., Butcher, S. G., Corrodi, H., Fuxe, K., Ungerstedt, U.: Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. Eur. J. Pharmacol. 11, 303–314 (1970)Google Scholar
  3. Andén, N.-E., Strömbom, U.: Adrenergic receptor blocking agents: Effects on central noradrenaline and dopamine receptors and on motor activity. Psychopharmacologia 38, 91–103 (1974)Google Scholar
  4. Bignami, G.: Pharmacologic influences on mating behavior in the male rat. Effects of d-amphetamine, LSD-25, strychnine, nicotine and various anticholinergic agents. Psychopharmacologia 10, 44–58 (1966)Google Scholar
  5. Carlsson, A., Corrodi, H., Fuxe, K., Hökfelt, T.: Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethylmetatyramine. Eur. J. Pharmacol. 5, 357–366 (1969a)Google Scholar
  6. Carlsson, A., Corrodi, H., Fuxe, K., Hökfelt, T.: Effects of some antidepressant drugs on the depletion of catecholamine stores caused by 4-methyl-α-ethyl-metatyramine. Eur. J. Pharmacol. 5, 367–373 (1969b)Google Scholar
  7. Eaton, H.: Clomipramine (Anafranil) in the treatment of premature ejaculation. J. Int. Med. Res. 1, 432–434 (1973)Google Scholar
  8. Green, M.: Inhibiton of ejaculation as a side effect of Mellaril. Am. J. Psychiatry 118, 172–173 (1961)Google Scholar
  9. Green, M., Berman, S.: Failure of ejaculation produced by dibenzyline. Conn. Med. 18, 30–33 (1954)Google Scholar
  10. Greenberg, H. R., Carillo, C.: Thioridazine-induced inhibition of masturbatory ejaculation in an adolescent. Am. J. Psychiat. 124, 991–993 (1968)Google Scholar
  11. Lindberg, M. H., Thorberg, S.-O., Bengtsson, S., Renyi, A. L., Ross, S. B., Ögren, S.-O.: Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by α-amino acid esters of phenethyl alcohols. J. Med. Chem. 21, 448–456 (1978)Google Scholar
  12. Meyerson, B., Malmnäs, C.-O.: Brain monoamines and sexual behavior. In: Biological determinants of sexual behavior, J. B. Hutchison, ed., pp. 521–554. Chichester: Wiley 1978Google Scholar
  13. Nakanishi, H., Kaneko, M.: Is thioridazine-induced ejaculation failure of peripheral origin? Res. Comm. Chem. Pathol. Pharmacol. 19, 549–552 (1978)Google Scholar
  14. Ross, S. B., Ögren, S.-O., Renyi, A. L.: (Z)-Dimethylamino-1-(4-bromhophenyl)-1-(3-pyridyl) propene (H 102/09), a new selective inhibitor of the neuronal 5-hydroxytryptamine uptake. Acta Pharmacol. Toxicol. (Kbh.) 39, 152–166 (1976)Google Scholar
  15. Ross, S. B., Renyi, A. L.: Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analogues. Neuropharmacology 16, 57–64 (1977)Google Scholar
  16. Singh, H.: Therapeutic use of thioridazine in premature ejaculation. Am. J. Psychiat. 119, 891 (1963)Google Scholar
  17. Snyder, S. H., Banerjee, S. P., Yamamura, H. I., Greenberg, D.: Drugs, neurotransmitters, and schizophrenia. Science 184, 1243–1253 (1974)Google Scholar
  18. Södersten, P., Larsson, K., Ahlenius, S., Engel, J.: Sexual behavior in castrated male rats treated with monoamine synthesis inhibitors and testosterone. Pharmacol. Biochem. Behav. 5, 319–327 (1976)Google Scholar
  19. Thursfield, D.: Anticholinergic effects of clomipramine (Anafranil). J. Int. Med. Res. 1, 456–459 (1973)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Sven Ahlenius
    • 1
    • 2
  • Mikael Heimann
    • 1
    • 2
  • Knut Larsson
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of GöteborgGöteborgSweden
  2. 2.Department of PsychologyUniversity of GöteborgGöteborgSweden

Personalised recommendations