Prolongation of the ejaculation latency in the male rat by thioridazine and chlorimipramine
Thioridazine (3 mg/kg) and chlorimipramine (1.5–6.0 mg/kg) prolonged the ejaculation latency and increased the number of mounts but did not change the number of intromissions preceding ejaculation. Blockade of peripheral and central noradrenaline receptors by phentolamine and phenoxybenzamine respectively resulted in a suppression of all aspects of the sexual behavior with increasing doses. dl-5-HTP (25–100 mg/kg) in combination with an inhibitor of peripheral 5-HTP decarboxylase (benserazide, 25 mg/kg) produced, like chlorimipramine and thioridazine, a prolongation of ejaculation latency and an increase in the number of mounts preceding ejaculation. Selective inhibition of 5-HT reuptake however, by zimelidine (0–20 mg/kg) or alaproclate (0–20 mg/kg) did not affect the mating behavior. At higher doses of these drugs some animals failed to initiate sexual activities. There was an increase in the postejaculatory interval but no change in the ejaculatory latency.
It is concluded that the prolonged ejaculation latencies observed following treatment with thioridazine or chlorimipramine is not due to a blockade of central or peripheral adrenergic α-receptors.
Key wordsMale sexual behavior Rat Monoamines Thioridazine Chlorimipramine
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- Ahlenius, S., Eriksson, H., Larsson, K., Modigh, K., Södersten, P.: Mating behavior in the male rat treated with p-chlorophenylalanine methyl ester alone and in combination with pargyline. Psychopharmacologia 20, 383–388 (1971)Google Scholar
- Andén, N.-E., Butcher, S. G., Corrodi, H., Fuxe, K., Ungerstedt, U.: Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. Eur. J. Pharmacol. 11, 303–314 (1970)Google Scholar
- Andén, N.-E., Strömbom, U.: Adrenergic receptor blocking agents: Effects on central noradrenaline and dopamine receptors and on motor activity. Psychopharmacologia 38, 91–103 (1974)Google Scholar
- Bignami, G.: Pharmacologic influences on mating behavior in the male rat. Effects of d-amphetamine, LSD-25, strychnine, nicotine and various anticholinergic agents. Psychopharmacologia 10, 44–58 (1966)Google Scholar
- Carlsson, A., Corrodi, H., Fuxe, K., Hökfelt, T.: Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethylmetatyramine. Eur. J. Pharmacol. 5, 357–366 (1969a)Google Scholar
- Carlsson, A., Corrodi, H., Fuxe, K., Hökfelt, T.: Effects of some antidepressant drugs on the depletion of catecholamine stores caused by 4-methyl-α-ethyl-metatyramine. Eur. J. Pharmacol. 5, 367–373 (1969b)Google Scholar
- Eaton, H.: Clomipramine (Anafranil) in the treatment of premature ejaculation. J. Int. Med. Res. 1, 432–434 (1973)Google Scholar
- Green, M.: Inhibiton of ejaculation as a side effect of Mellaril. Am. J. Psychiatry 118, 172–173 (1961)Google Scholar
- Green, M., Berman, S.: Failure of ejaculation produced by dibenzyline. Conn. Med. 18, 30–33 (1954)Google Scholar
- Greenberg, H. R., Carillo, C.: Thioridazine-induced inhibition of masturbatory ejaculation in an adolescent. Am. J. Psychiat. 124, 991–993 (1968)Google Scholar
- Lindberg, M. H., Thorberg, S.-O., Bengtsson, S., Renyi, A. L., Ross, S. B., Ögren, S.-O.: Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by α-amino acid esters of phenethyl alcohols. J. Med. Chem. 21, 448–456 (1978)Google Scholar
- Meyerson, B., Malmnäs, C.-O.: Brain monoamines and sexual behavior. In: Biological determinants of sexual behavior, J. B. Hutchison, ed., pp. 521–554. Chichester: Wiley 1978Google Scholar
- Nakanishi, H., Kaneko, M.: Is thioridazine-induced ejaculation failure of peripheral origin? Res. Comm. Chem. Pathol. Pharmacol. 19, 549–552 (1978)Google Scholar
- Ross, S. B., Ögren, S.-O., Renyi, A. L.: (Z)-Dimethylamino-1-(4-bromhophenyl)-1-(3-pyridyl) propene (H 102/09), a new selective inhibitor of the neuronal 5-hydroxytryptamine uptake. Acta Pharmacol. Toxicol. (Kbh.) 39, 152–166 (1976)Google Scholar
- Ross, S. B., Renyi, A. L.: Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analogues. Neuropharmacology 16, 57–64 (1977)Google Scholar
- Singh, H.: Therapeutic use of thioridazine in premature ejaculation. Am. J. Psychiat. 119, 891 (1963)Google Scholar
- Snyder, S. H., Banerjee, S. P., Yamamura, H. I., Greenberg, D.: Drugs, neurotransmitters, and schizophrenia. Science 184, 1243–1253 (1974)Google Scholar
- Södersten, P., Larsson, K., Ahlenius, S., Engel, J.: Sexual behavior in castrated male rats treated with monoamine synthesis inhibitors and testosterone. Pharmacol. Biochem. Behav. 5, 319–327 (1976)Google Scholar
- Thursfield, D.: Anticholinergic effects of clomipramine (Anafranil). J. Int. Med. Res. 1, 456–459 (1973)Google Scholar