Abstract
Thioridazine (3 mg/kg) and chlorimipramine (1.5–6.0 mg/kg) prolonged the ejaculation latency and increased the number of mounts but did not change the number of intromissions preceding ejaculation. Blockade of peripheral and central noradrenaline receptors by phentolamine and phenoxybenzamine respectively resulted in a suppression of all aspects of the sexual behavior with increasing doses. dl-5-HTP (25–100 mg/kg) in combination with an inhibitor of peripheral 5-HTP decarboxylase (benserazide, 25 mg/kg) produced, like chlorimipramine and thioridazine, a prolongation of ejaculation latency and an increase in the number of mounts preceding ejaculation. Selective inhibition of 5-HT reuptake however, by zimelidine (0–20 mg/kg) or alaproclate (0–20 mg/kg) did not affect the mating behavior. At higher doses of these drugs some animals failed to initiate sexual activities. There was an increase in the postejaculatory interval but no change in the ejaculatory latency.
It is concluded that the prolonged ejaculation latencies observed following treatment with thioridazine or chlorimipramine is not due to a blockade of central or peripheral adrenergic α-receptors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ahlenius, S., Eriksson, H., Larsson, K., Modigh, K., Södersten, P.: Mating behavior in the male rat treated with p-chlorophenylalanine methyl ester alone and in combination with pargyline. Psychopharmacologia 20, 383–388 (1971)
Andén, N.-E., Butcher, S. G., Corrodi, H., Fuxe, K., Ungerstedt, U.: Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. Eur. J. Pharmacol. 11, 303–314 (1970)
Andén, N.-E., Strömbom, U.: Adrenergic receptor blocking agents: Effects on central noradrenaline and dopamine receptors and on motor activity. Psychopharmacologia 38, 91–103 (1974)
Bignami, G.: Pharmacologic influences on mating behavior in the male rat. Effects of d-amphetamine, LSD-25, strychnine, nicotine and various anticholinergic agents. Psychopharmacologia 10, 44–58 (1966)
Carlsson, A., Corrodi, H., Fuxe, K., Hökfelt, T.: Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethylmetatyramine. Eur. J. Pharmacol. 5, 357–366 (1969a)
Carlsson, A., Corrodi, H., Fuxe, K., Hökfelt, T.: Effects of some antidepressant drugs on the depletion of catecholamine stores caused by 4-methyl-α-ethyl-metatyramine. Eur. J. Pharmacol. 5, 367–373 (1969b)
Eaton, H.: Clomipramine (Anafranil) in the treatment of premature ejaculation. J. Int. Med. Res. 1, 432–434 (1973)
Green, M.: Inhibiton of ejaculation as a side effect of Mellaril. Am. J. Psychiatry 118, 172–173 (1961)
Green, M., Berman, S.: Failure of ejaculation produced by dibenzyline. Conn. Med. 18, 30–33 (1954)
Greenberg, H. R., Carillo, C.: Thioridazine-induced inhibition of masturbatory ejaculation in an adolescent. Am. J. Psychiat. 124, 991–993 (1968)
Lindberg, M. H., Thorberg, S.-O., Bengtsson, S., Renyi, A. L., Ross, S. B., Ögren, S.-O.: Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by α-amino acid esters of phenethyl alcohols. J. Med. Chem. 21, 448–456 (1978)
Meyerson, B., Malmnäs, C.-O.: Brain monoamines and sexual behavior. In: Biological determinants of sexual behavior, J. B. Hutchison, ed., pp. 521–554. Chichester: Wiley 1978
Nakanishi, H., Kaneko, M.: Is thioridazine-induced ejaculation failure of peripheral origin? Res. Comm. Chem. Pathol. Pharmacol. 19, 549–552 (1978)
Ross, S. B., Ögren, S.-O., Renyi, A. L.: (Z)-Dimethylamino-1-(4-bromhophenyl)-1-(3-pyridyl) propene (H 102/09), a new selective inhibitor of the neuronal 5-hydroxytryptamine uptake. Acta Pharmacol. Toxicol. (Kbh.) 39, 152–166 (1976)
Ross, S. B., Renyi, A. L.: Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analogues. Neuropharmacology 16, 57–64 (1977)
Singh, H.: Therapeutic use of thioridazine in premature ejaculation. Am. J. Psychiat. 119, 891 (1963)
Snyder, S. H., Banerjee, S. P., Yamamura, H. I., Greenberg, D.: Drugs, neurotransmitters, and schizophrenia. Science 184, 1243–1253 (1974)
Södersten, P., Larsson, K., Ahlenius, S., Engel, J.: Sexual behavior in castrated male rats treated with monoamine synthesis inhibitors and testosterone. Pharmacol. Biochem. Behav. 5, 319–327 (1976)
Thursfield, D.: Anticholinergic effects of clomipramine (Anafranil). J. Int. Med. Res. 1, 456–459 (1973)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ahlenius, S., Heimann, M. & Larsson, K. Prolongation of the ejaculation latency in the male rat by thioridazine and chlorimipramine. Psychopharmacology 65, 137–140 (1979). https://doi.org/10.1007/BF00433039
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00433039