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Effects of trifluoperazine, chlorpromazine, and haloperidol upon temporal information processing by schizophrenic patients

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Abstract

Healthy controls, unmedicated, actively symptomatic schizophrenics, and similar patients undergoing treatment with either trifluoperazine, chlorpromazine, or haloperidol were studied with tests of temporal discrimination and measures of transmitted information shown previously to be sensitive to various kinds of brain dysfunction, including haloperidol effects in a nonpsychotic population. Variations in psychophysical method, cognitive load, discrimination complexity, and sense-mode conditions permitted representative sampling of the temporai processing. Untreated, actively psychotic patients showed no impairment of temporal processing while all three antipsychotic medications were associated with significant deficit; trifluoperazine and haloperidol produced the most deficit, with chlorpromazine in the middle between the higher potency drugs on the one hand and unmedicated patients and healthy controls on the other.

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Authors and Affiliations

  1. Cornell University Medical College, 21 Bloomingdale Road, 10605, White Plains, NY, USA

    H. George Nurnberg

  2. Department of Psychology, University of Maine at Orono, 04469, Orono, Maine, USA

    Sanford Goldstone & William T. Lhamon

Authors
  1. Sanford Goldstone
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  2. H. George Nurnberg
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  3. William T. Lhamon
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Edward W. Bourne Behavioral Research Laboratories

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Goldstone, S., Nurnberg, H.G. & Lhamon, W.T. Effects of trifluoperazine, chlorpromazine, and haloperidol upon temporal information processing by schizophrenic patients. Psychopharmacology 65, 119–124 (1979). https://doi.org/10.1007/BF00433037

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  • DOI: https://doi.org/10.1007/BF00433037

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