Psychopharmacology

, Volume 56, Issue 3, pp 305–308 | Cite as

Methylxanthine-facilitated shock-induced aggression in the rat

  • Burr Eichelman
  • Elaine Orenberg
  • Pamela Hackley
  • Jack Barchas
Article

Abstract

The methylxanthines caffeine and aminophylline, in daily doses of 100 mg/kg, facilitated shock-induced aggression in the rat. Under the limited parameters of this study, there was no induction of mouse-killing behavior or alteration of jump thresholds. Additional studies showed the optimal dose and time course for the facilitation of shock-induced aggression by caffeine to be 50 mg/kg administered i.p. 4 h prior to testing. Facilitation of a central adrenergic system may be the mechanism of action.

Key words

Caffeine Aminophylline Shock-induced aggression Aggressive behavior Mouse-killing Pain thresholds 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Belluzi, J. D., Grossman, S. P.: A source of scrambled constant current with solid state control. Physiol. Behav. 10, 133–135 (1973)Google Scholar
  2. Berkowitz, J. H., Tarver, J. H., Spector, S.: Release of norepinephrine in the central nervous system by theophylline and caffeine. Eur. J. Pharmacol. 10, 64–71 (1970)Google Scholar
  3. Cheung, W. Y.: Properties of cyclic 3′,5′-nucleotide phosphodiesterase from rat brain. Biochemistry 6, 1079–1087 (1967)Google Scholar
  4. Crawley, J. N., Contrera, J. F.: Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice. Pharmacol. Biochem. Behav. 4, 381–384 (1976)Google Scholar
  5. Eichelman, B.: Effect of subcortical lesions on shock-induced aggression in the rat. J. Comp. Physiol. Psychol. 74, 331–339 (1971)Google Scholar
  6. Eichelman, B.: The catecholamines and aggressive behavior. Neurosci. Res. 5, 109–129 (1973)Google Scholar
  7. Eichelman, B., Thoa, N. B., Ng, K. Y.: Facilitated aggression in the rat following 6-hydroxydopamine administration. Physiol. Behav. 8, 1–3 (1972)Google Scholar
  8. Hughes, F. W., Forney, R. B.: Alcohol and caffeine in choice-discrimination tests in rats. Proc. Soc. Exp. Biol. Med. 108, 157–159 (1961)Google Scholar
  9. Jones, A. B., Barchas, J. D., Eichelman, B.: Taming effects of p-chlorophenylalanine on the aggressive behavior of septal rats. Pharmacol. Biochem. Behav. 4, 397–400 (1976)Google Scholar
  10. Lints, C. E., Harvey, J. A.: Brain content of serotonin following brain lesions in the rat. J. Comp. Physiol. Psychol. 67, 23–31 (1969)Google Scholar
  11. Orenberg, E. K., Renson, J., Elliott, G. R., Barchas, J. D., Kessler, S.: Genetic determination of aggressive behavior and brain cyclic AMP. Psychopharmacol. Commun. 1, 99–107 (1975)Google Scholar
  12. Quenzer, L. F., Feldman, R. S., Moore, J. W.: Toward a mechanism of the anti-aggression effects of chlordiazepoxide in rats. Psychopharmacologia (Berl.) 34, 81–94 (1974)Google Scholar
  13. Sakata, T., Fuchimoto, H.: Stereotyped and aggressive behavior induced by sustained high dose of theophylline in rats. Jpn. J. Pharmacol. 23, 781–785 (1973a)Google Scholar
  14. Sakata, T., Fuchimoto, H.: Further aspects of aggressive behavior induced by sustained high dose of theophylline in rats. Jpn. J. Pharmacol. 23, 787–792 (1973b)Google Scholar
  15. Scott, C. C., Anderson, R. C., Chen, K. K.: Further study of some l-substituted theobromine compounds. J. Pharmacol. Exp. Ther. 84, 113–119 (1945)Google Scholar
  16. Sheard, M., Davis, M.: Shock elicited fighting in rats: importance of intershock interval upon the effect of p-chlorophenylalanine (PCPA). Brain Res. 111, 433–437 (1976)Google Scholar
  17. Skolnick, P., Daly, J. W.: Norepinephrine-sensitive adenylate cyclases in rat brain: relation to behavior and tyrosine hydroxylase. Science 184, 175–177 (1974)Google Scholar
  18. Valzelli, L., Bernasconi, S.: Behavioral and neurochemical effects of caffeine in normal and aggressive mice. Pharmacol. Biochem. Behav 1, 251–254 (1973)Google Scholar
  19. Waldeck, B.: Some effects of caffeine and aminophylline on the turnover of catecholamines in the brain. J. Pharm. Pharmacol. 23, 824–830 (1971)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Burr Eichelman
    • 1
  • Elaine Orenberg
    • 1
  • Pamela Hackley
    • 1
  • Jack Barchas
    • 1
  1. 1.Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA

Personalised recommendations