, Volume 56, Issue 3, pp 305–308 | Cite as

Methylxanthine-facilitated shock-induced aggression in the rat

  • Burr Eichelman
  • Elaine Orenberg
  • Pamela Hackley
  • Jack Barchas


The methylxanthines caffeine and aminophylline, in daily doses of 100 mg/kg, facilitated shock-induced aggression in the rat. Under the limited parameters of this study, there was no induction of mouse-killing behavior or alteration of jump thresholds. Additional studies showed the optimal dose and time course for the facilitation of shock-induced aggression by caffeine to be 50 mg/kg administered i.p. 4 h prior to testing. Facilitation of a central adrenergic system may be the mechanism of action.

Key words

Caffeine Aminophylline Shock-induced aggression Aggressive behavior Mouse-killing Pain thresholds 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Burr Eichelman
    • 1
  • Elaine Orenberg
    • 1
  • Pamela Hackley
    • 1
  • Jack Barchas
    • 1
  1. 1.Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA

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