, Volume 56, Issue 3, pp 249–253

PRL-8-53: Enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent

  • Nikolaus R. Hansl
  • Beverley T. Mead

DOI: 10.1007/BF00432846

Cite this article as:
Hansl, N.R. & Mead, B.T. Psychopharmacology (1978) 56: 249. doi:10.1007/BF00432846


The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride (PRL-8-53) on learning and on retention of verbal information in human subjects was investigated. Using the serial anticipation method under double-blind conditions it was found that PRL-8-53 causes slight improvement of acquisition. Retention of verbal information was found improved to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either visual reaction time or motor control after drug when compared with placebo values.

Key words

Learning Memory Benzoic acid derivatives Phenethylamines 

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Nikolaus R. Hansl
    • 1
  • Beverley T. Mead
    • 1
  1. 1.Department of Medicinal Chemistry and Department of PsychiatryCreighton UniversityOmahaUSA

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