PRL-8-53: Enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent
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- Hansl, N.R. & Mead, B.T. Psychopharmacology (1978) 56: 249. doi:10.1007/BF00432846
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The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride (PRL-8-53) on learning and on retention of verbal information in human subjects was investigated. Using the serial anticipation method under double-blind conditions it was found that PRL-8-53 causes slight improvement of acquisition. Retention of verbal information was found improved to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either visual reaction time or motor control after drug when compared with placebo values.