Abstract
Forty male volunteers were randomly assigned to one of four treatment groups on a doubleblind basis: (1) Imipramine-25 mg t.d.s., (2) Viloxazine-50 mg t.d.s., (3) Placebo, and (4) Control-no tablets. Tests were carried out (1) before treatment, (2) 2 h after the first dose, (3) on Day 3 after 7 doses, and (4) on Day 7 after 21 doses. The driving tasks consisted of (1) weaving around a series of bollards while simultaneously responding to an auditory logic task and (2) a gap acceptance task. Using an analysis of covariance repeated measures design, it was found that imipramine tended to increase the level of risk acceptable to the subject as compared to either placebo or control. Imipramine also impaired performance on other tasks. Viloxazine appeared to be little different from either placebo or control on any of the tasks.
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References
Automobile Association: The drugged driver. Drive Magazine 1, 30–35 (1969)
Bayliss, P. F. C., Duncan, S. M.: The clinical pharmacology of viloxazine hydrochloride—a new anti-depressant of novel chemical structure. Br. J. Clin. Pharmacol. 1 431–437 (1974)
Campbell, D. T., Stanley, J. C.: Experimental and quasi-experimental designs for research Chicago: Rand McNally (1963)
Clayton, A. B.: The effects of psychotropic drugs on driving-related skills. Hum. Factors 18, 241–252 (1976)
Clayton, A. B., Betts, T. A., Harvey, P. G.: The influence of sex and personality factors upon the effect of tranquillizers on driving performance. In: Proc. of 6th International Conference on Alcohol, Drugs, and Traffic Safety, pp. 415–422. Toronto: Addiction Research Foundation 1974
Cohen, J., Dearnaley, E. J., Hansel, C. E. M.: The risk taken in driving under the influence of alcohol. Br. Med. J. 1958II, 1438–1442
Department of Health and Social Security: Health and personal social services statistics for England, 1975. London: Her Majesty's Stationery Office 1976
DiMascio, A., Heninger, G., Klerman, G. L.: Psychopharmacology of imipramine and desimipramine: a comparative study of their effects in normal males. Psychopharmacologia (Berl.) 5, 361–371 (1964)
Eysenck, H. J., Eysenck, S. B. G.: Manual of the Eysenck personality inventory. London: University of London Press 1964
Idestrom, C. M., Cadenius, B.: Imipramine-desmethyl-imipramine. A pharmacological study on human beings. Psychopharmacologia (Berl.) 5, 431–439 (1964)
Keeler, M. H., Prange, A. J., Reifler, C. B.: Effects of imipramine and thioridiazine on set and attention In: Proc. of 4th World Congress of Psychiatry, Madrid, 1966 (International Congress Series 150) pp. 2069–2072. J. J. Lopez Ibor, ed. Amsterdam: Exerpta Medica 1968
Kibrick, E., Smart, R. G.: Psychotropic drug use and driving risk: a review and analysis. J. Safety Res. 2, 73–85 (1970)
Kirby, M., Turner, P.: Some preliminary observations on ICI 58,834, a new psychotropic agent in man. Br. J. Clin. Pharmacol. 1, 169 (1974)
Landauer, A. A., Milner, G.: Desipramine and imipramine, alone and together with alcohol in relation to driving safety. Pharmakopsychiatr. Neuropsychopharmakol. 4, 265–275 (1971)
Mallion, K. B., Todd, A. H., Turner, R. W., Bainbridge, J. G., Greenwood, D. T., Madinaveitia, J., Somerville, A. R., Whittle, B. A.: 2-(2-Ethoxyphenoxymethyl)tetrahydro-1,4-oxazine hydrochloride, a potential psychotropic agent. Nature (Lond.) 238, 157–158 (1972)
Winer, B. J.: Statistical principles in experimental design. New York: McGraw Hill 1971
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Clayton, A.B., Harvey, P.G. & Betts, T.A. The effects of two antidepressants, imipramine and viloxazine, upon driving performance. Psychopharmacology 55, 9–12 (1977). https://doi.org/10.1007/BF00432810
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DOI: https://doi.org/10.1007/BF00432810